cNeuro cDAT
Automated quantification of DAT SPECT images for neurological disorders
Company profile
Company profile
Combinostics is a medical imaging AI company specializing in neurological disorders, offering the only complete AI solution for entire patient care pathways of major neurodegenerative diseases. Founded by experts with over 20 years of neuroimaging experience, the company developed the cNeuro platform, which integrates multiple applications to support clinicians from early detection through disease management. The cNeuro platform consists of cMRI for fully automated brain MRI quantification, cDSI for AI-supported differential diagnosis and disease progression prediction, cPET for amyloid and FDG brain PET quantification, and cDAT for automated quantification of DAT SPECT images. The platform combines imaging biomarkers with clinical data, neuropsychological tests, and demographic information to provide comprehensive patient insights. Combinostics serves radiologists, neurologists, and memory clinics across health systems, enabling better collaboration between disciplines. The company's solutions support diagnosis of Alzheimer's disease, frontotemporal dementia, vascular dementia, dementia with Lewy bodies, and multiple sclerosis. With validated imaging biomarkers and machine learning methods trained on data from over 2,000 patients with confirmed neurodegenerative diseases, cNeuro provides quantitative, objective information that helps clinicians make earlier, more confident diagnoses and data-driven decisions about additional testing. The company maintains strong partnerships with leading Nordic institutions and the international clinical community.
Company description Combinostics official website
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01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Cloud Saas deployment with recorded integration context.
Company milestones
Acquisition agreement with SyntheticMR announced November 2024; cDAT application for DAT SPECT quantification released in Europe December 2023; cPET application received FDA 510(k) clearance September 2023; cPET application released in Europe July 2023; Participation in PROMINENT Project for precision medicine in neurodegenerative diseases June 2023
Partnerships
02 · Flagship portfolio
Selected source-backed Company products and the available commercial context.
Automated quantification of DAT SPECT images for neurological disorders
AI-supported differential diagnosis and prediction of neurodegenerative diseases
Fully automated brain MRI quantification for radiologists
Automated quantification of amyloid and FDG brain PET imaging
MRI-based differential diagnosis report for neurodegenerative diseases
03 · Research intelligence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
Neurology · Sep 8, 2026
A magnetic resonance imaging analysis of cognitively discordant monozygotic and dizygotic twins: a comparative study of visual rating method and tensor-based morphometry.Acta radiologica (Stockholm, Sweden : 1987) · Aug 4, 2026
Orbitofrontal atrophy on MRI appears to be an indicator of C9orf72 repeat expansion status in FTD.Journal of neuroradiology = Journal de neuroradiologie · Jun 16, 2026
Comparability of Centiloid values from [18F]flutemetamol scans using seven commercial and research software.Neuroimage. Reports · Jun 1, 2026
Brain ventricle morphology markers in predicting shunt surgery outcome in idiopathic normal-pressure hydrocephalus.Fluids and barriers of the CNS · Apr 9, 2026
Network Localization of Fatigue in Multiple Sclerosis.Annals of clinical and translational neurology · Apr 1, 2026
Clinical validation
NCT05565170 · Sponsor · COMPLETED
Regulatory
K171328 · 510k · Jan 8, 2018
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
Enables more confident, earlier diagnosis of neurodegenerative diseases
Quantified information helps with differential diagnosis in memory clinics
Helps clinicians make evidence-based decisions about whether additional testing is necessary
Using cMRI for more objective data and integrations in software-driven imaging quantification in neuroradiology
Benefits seen from tools such as cMRI for objective data in neuroradiology workflows
Daily use for all dementia investigations and some MS patients, particularly useful in intermediate situations with doubt about existence or type of atrophy and for assessing follow-up scans
cNeuro usage and reporting are highly appreciated by referring physicians
Using cNeuro for differential diagnosis and assessing whether cognitive issues are due to dementia in memory clinic patients
cNeuro has become an indispensable tool for the memory clinic, with quantified information helping with differential diagnosis
Getting quantitative information when reading scans and sharing imaging information with referring organizations to enable combination of imaging data with clinical data in cNeuro cDSI
Enables sharing of imaging information with referring organizations for comprehensive patient data analysis
05 · Leadership
Leadership profiles and professional links from the current Company record.
Lennart Thurfjell
Chief Operating Officer (COO) and Co-Founder
Jyrki Lötjönen
Chief Scientific Officer (CSO) and Co-Founder
Jussi Mattila
Chief Technology Officer (CTO) and Co-Founder
Mikael Dahlke
Head of Quality Assurance
Elena Bonke
Medical Science Liaison, Clinical App Specialist
Juha Koikkalainen
Senior Imaging Scientist
Antti Tolonen
Senior Imaging Scientist
Markus Niiranen
Lead Software Developer / Team Manager
06 · Company updates
Recent articles published on Combinostics's official website.
07 · HAIC coverage
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08 · Official presence
Curated official destinations from the active Company record.
09 · Market pathway
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Market context
Companies that apply AI to analyze medical images for diagnostic purposes, workflow optimization, or clinical decision support. Covers general radiology (X-rays, CT scans, MRIs, ultrasounds) across multiple organ systems, as well as specialized imaging in ophthalmology and dermatology.
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