Evaluating the Effect of Neighborhood-level Disadvantage on Brain Health: An Imaging Epidemiology Study.

Ethan H Willbrand^1,2,3, Elizabeth M Stoeckl², Daryn Belden², Sheena Y Chu⁴, Eleanna M Melcher^5,6, Daniil Zhitnitskii⁷, Elena Bonke⁷, Jussi Mattila⁷, Usman Iftikhar⁷, Juha Koikkalainen⁷, Antti Tolonen⁷, Jyrki Lötjönen⁷, Richard Bruce², John-Paul J Yu^1,2,3,8,9,10

¹Medical Scientist Training Program, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

²Department of Radiology, University of Wisconsin School of Medicine and Public Health, 1111 Highland Ave, Madison, WI 53705.

³Neuroscience Training Program, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

⁴Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

⁵Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

⁶Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, Wis.

⁷Combinostics, Tampere, Finland.

⁸Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

⁹Department of Biomedical Engineering, College of Engineering, University of Wisconsin-Madison, Madison, Wis.

¹⁰Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wis.

PubMed PMC DOI PDF

Abstract

Background The relationship between neighborhood-level socioeconomic disadvantage and brain health is an emerging area of research with critical implications for public health and clinical practice, yet its association with brain structure remains unclear. Purpose To investigate the epidemiologic association between neighborhood-level socioeconomic disadvantage (measured using the Area Deprivation…

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