Peer-Reviewed Publication
Neurology2026;107(5):e218418.September 8, 2026Journal Article
Comparison of Brain Age With Standard MRI Assessment for Dementia Risk Stratification in Subjective and Mild Cognitive Impairment.
Stefan De Vries1,2, Katalin Farkas1,2, Hanneke F M Rhodius-Meester3,4,5, Argonde Corien Van Harten4,5, Calvin Trieu4,5, Alle Meije Wink1,2, Lyduine E Collij1,2, Jyrki Lötjönen6, Wiesje M Van Der Flier4,7,8,9, Frederik Barkhof1,2,10, Bas Jasperse1,2, Mara Ten Kate1,2
1Department of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, the Netherlands.
2Amsterdam Neuroscience, Brain Imaging, the Netherlands.
3Geriatric Medicine, The Memory Clinic, Oslo University Hospital, Norway.
4Amsterdam Neuroscience, Neurodegeneration, the Netherlands.
5Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, the Netherlands.
6Combinostics Ltd, Tampere, Finland.
7Alzheimer Nederland, Amersfoort, the Netherlands.
8Epidemiology and Biostatistics, Vrije Universiteit Amsterdam, Amsterdam UMC, location VUmc, the Netherlands.
9Amsterdam Public Health, the Netherlands; and.
10University College London (UCL), United Kingdom.
Abstract
BACKGROUND AND OBJECTIVES: Early dementia risk-stratification is crucial for timely intervention. Brain-predicted age difference (brain-PAD) derived from structural MRI reflects the gap between computer-estimated age and chronological age and has been linked to clinical progression to dementia. We evaluate whether brain-PAD has prognostic value for progression to dementia in subjective cognitive d…
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