Feasibility, image quality, and analytic usability of mobile 64 mT ultra-low-field MRI for infant brain imaging at 3 and 12 months in southern Malawi.

Maclean Vokhiwa^1,2, Karen Chetcuti³, Frederik Lange⁴, Niall J Bourke⁵, Louise Randall⁶, Steven Greenstein⁷, Marc Seal⁷, Richard Beare⁷, Adam Hussain⁸, Padma Rao⁸, Emil Ljungberg^9,10, Francesco Padormo¹¹, John Rogers¹¹, Pip Torelli¹¹, Steve Williams⁵, Derek K Jones¹², Sean C L Deoni¹³, Sant-Rayn Pasricha⁶, Kamija S Phiri^1,2, Eric Umar²,

¹Training & Research Unit of Excellence (TRUE), Blantyre, Malawi.

²Kamuzu University of Health Sciences (KUHeS), Blantyre, Malawi.

³Department of Radiology, Kamuzu University of Health Sciences (KUHeS), Blantyre, Malawi.

⁴Centre for Integrative Neuroimaging (OxCIN), FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, United Kingdom.

⁵Centre for Neuroimaging Sciences, Department of Psychology and Neuroscience, King's College London, London, United Kingdom.

⁶Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.

⁷Developmental Imaging, Murdoch Children's Research Institute, The Royal Children's Hospital, Victoria, Australia.

⁸Department of Medical Imaging, The Royal Children's Hospital, Parkville, Victoria, Australia.

⁹Department of Neuroimaging, King's College London, London, United Kingdom.

¹⁰Department of Medical Radiation Physics, Lund University, Lund, Sweden.

¹¹Hyperfine, Inc., Guilford, CT, USA.

¹²Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom.

¹³Maternal, Newborn, Child Nutrition & Health, Gates Foundation, Seattle, WA, United States.

PubMed PMC DOI PDF

Abstract

Mobile ultra-low-field MRI (ULF-MRI) could reduce inequities in infant neuroimaging in sub-Saharan Africa, but evidence of its feasibility, image quality, and analytic usability remains limited. We evaluated the feasibility, image quality, and analytic usability of mobile 64 mT ULF-MRI for non-sedated infant brain imaging at three and twelve months of age within a longitudinal trial platform in so…

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