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Peer-Reviewed Publication
J Am Med Dir Assoc2026;27(11):106473.September 3, 2026Journal Article

Elderly Health Check-Up and Functional Disability or Death in Adults 75 to 84 Years: A Target Trial Emulation.

Ryohei Yamamoto1, Hajime Yamazaki2, Hiroaki Nakagawa3, Akihiro Ozaka4, Sho Sasaki5, Sayaka Shimizu6, Sugihiro Hamaguchi7, Shunichi Fukuhara8
1Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University Hospital, Fukushima, Japan; Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: ryoheiyamamoto11@gmail.com.
2Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University Hospital, Fukushima, Japan; Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
3Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University Hospital, Fukushima, Japan; Center for General Internal Medicine and Family Medicine, Fukushima Medical University, Fukushima, Japan; Department of General Internal Medicine and Family Medicine, Fukushima Medical University, Fukushima, Japan.
4Department of General Medicine, Shirakawa Satellite for Teaching and Research (STAR), Fukushima Medical University, Fukushima, Japan.
5Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University Hospital, Fukushima, Japan; Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of General Medicine, Iwase Satellite for Teaching and Research (STAR), Fukushima Medical University, Fukushima, Japan.
6Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Patient Driven Academic League (PeDAL), Kyoto, Japan.
7Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University Hospital, Fukushima, Japan; Department of General Internal Medicine and Family Medicine, Fukushima Medical University, Fukushima, Japan.
8Center for Innovative Research for Communities and Clinical Excellence (CiRC2LE), Fukushima Medical University Hospital, Fukushima, Japan; Section of Clinical Epidemiology, Department of Community Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan; Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health (JHSPH), Baltimore, MD, USA.
PubMed DOI

Abstract

OBJECTIVES: To estimate the effect of initial Elderly Health Check-up (EHC) attendance on the 5-year risk of functional disability or death in community-dwelling older adults in a setting where preventing entry into long-term care (LTC) is a primary health-policy goal. DESIGN: Sequential target trial emulation using a population-based cohort. SETTING AND PARTICIPANTS: Community-dwelling adults a…

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