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Peer-Reviewed Publication
Int J Clin Oncol2026August 20, 2026Journal Article

Clinical significance of WES-defined ERBB2 amplification in resectable colorectal cancer.

Kazuki Kishi1, Atsushi Hamabe2, Yusuke Suwa3, Naoya Akazawa4, Keiji Hirata5, Masataka Ikeda6, Mitsuru Yokota7, Kentaro Kato8, Masahito Kotaka9, Yujiro Nishizawa10, Hideaki Bando11, Yoshiaki Nakamura11, Saori Mishima11, Tadayoshi Hashimoto11, Arkarachai Fungtammasan12, Charuta C Palsuledesai12, Robert W Lentz12, Daisuke Kotani11, Hiroya Taniguchi13, Jun Watanabe14, Ichiro Takemasa15, Takeshi Kato16, Mamoru Uemura1, Hidetoshi Eguchi1, Yuichiro Doki1, Eiji Oki17, Takayuki Yoshino11
1Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan.
2Department of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan. ahamabe@gesurg.med.osaka-u.ac.jp.
3Department of Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Kanagawa, Japan.
4Department of Gastroenterological Surgery, Sendai City Medical Center (Sendai Open Hospital), Sendai, Miyagi, Japan.
5Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan.
6Division of Colorectal Surgery, Department of Gastrointestinal Surgery, Hyogo Medical University, Hyogo, Japan.
7Department of General Surgery, Kurashiki Central Hospital, Kurashiki, Okayama, Japan.
8Department of Surgery, Teine-Keijinkai Hospital, Sapporo, Hokkaido, Japan.
9Gastrointestinal Cancer Center, Sano Hospital, Kobe, Hyogo, Japan.
10Department of Gastroenterological Surgery, Osaka General Medical Center, Sumiyoshi-ku, Osaka, Japan.
11Department of Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
12Natera, Inc, Austin, TX, USA.
13Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan.
14Department of Colorectal Surgery, Kansai Medical University, Hirakata, Osaka, Japan.
15Department of Gastroenterological Surgery, Osaka International Medical and Science Center, Osaka City, Osaka, Japan.
16NHO Osaka National Hospital, Chuo-ku, Osaka, Japan.
17Department of Advanced Medicine and Innovative Technology, Kyushu University, Higashi-ku, Fukuoka, Japan.
PubMed DOI

Abstract

BACKGROUND: HER2 amplification is demonstrated to influence response to therapy and outcomes in metastatic colorectal cancer (mCRC), but its role in resectable CRC remains unclear. This study investigated the prognostic impact of WES-defined ERBB2 amplification and its association with adjuvant chemotherapy (ACT) efficacy and circulating tumor DNA (ctDNA) in resectable CRC. METHODS: Data from 360…

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