Virus-like particles vaccine of porcine epidemic diarrhea virus spike 1 protein induces protective immunity challenge in piglets.

Zhiqiang Li¹, Jie Li¹, Jiahai Cheng¹, Guigang Zhang¹, Mingzhi Zhao¹, Zhen Wang²

¹Jinyu Baoling Bio-pharmaceutical Co., Ltd., Hohhot, Inner Mongolia, 010111, China.

²Animal Disease Prevention and Control Center of Tuquan County, Xing'an League, Inner Mongolia, 137500, China.

Abstract

Porcine epidemic diarrhea virus (PEDV) is a highly contagious intestinal disease that impairs piglet growth and development, causing significant economic losses. Therefore, developing an effective vaccine is crucial for preventing and controlling PEDV. This study used a eukaryotic expression system to assemble S1 with Ferritin into virus-like particles (S1-F-VLP) via SpyTag-SpyCatcher and confirme…

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