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Peer-Reviewed Publication
Mol Cell2026August 17, 2026Journal Article

Maintenance of nucleosome organization through replication and transcription counteracts aberrant coalescence of active chromatin.

R Ciaran MacKenzie Frater1, Rikke Rejnholdt Jensen1, Joaquim Ollé López1, Valentin Flury2, Jeroen van den Berg3, Jonathan Humbert1, Anton Bournonville2, Nicolas Alcaraz1, Simai Wang4, Hannah J Richter4, Marty G Yang4, Qian Du5, Alexander van Oudenaarden3, Vijay Ramani6, Nils Krietenstein7, Anja Groth8
1Center for Epigenetic Cell Memory (EpiC), Danish Cancer Institute, Danish Cancer Society, 2100 Copenhagen, Denmark; Novo Nordisk Foundation Center for Protein Research (CPR), Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark.
2Novo Nordisk Foundation Center for Protein Research (CPR), Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark.
3Hubrecht Institute, KNAW & University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands; Oncode Institute, the Netherlands.
4Gladstone Institute for Data Science & Biotechnology, San Francisco, CA 94158, USA.
5Center for Epigenetic Cell Memory (EpiC), Danish Cancer Institute, Danish Cancer Society, 2100 Copenhagen, Denmark; Novo Nordisk Foundation Center for Protein Research (CPR), Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark; Garvan Institute of Medical Research, St Vincent's Clinical School, University of New South Wales, Sydney, NSW, Australia.
6Gladstone Institute for Data Science & Biotechnology, San Francisco, CA 94158, USA; Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA.
7Center for Epigenetic Cell Memory (EpiC), Danish Cancer Institute, Danish Cancer Society, 2100 Copenhagen, Denmark; Novo Nordisk Foundation Center for Protein Research (CPR), Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: nilkri@cancer.dk.
8Center for Epigenetic Cell Memory (EpiC), Danish Cancer Institute, Danish Cancer Society, 2100 Copenhagen, Denmark; Novo Nordisk Foundation Center for Protein Research (CPR), Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen, Denmark; Biotech Research & Innovation Centre, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: anja.groth@cancer.dk.
PubMed DOI

Abstract

Nucleosomes with their associated modifications organize and regulate the genome. It is unclear how this is integrated with the requirement of replication and transcription to access the DNA template without jeopardizing chromatin function. Here, we reveal a unified requirement for the histone chaperone FACT in mediating nucleosome disruption and reassembly during mammalian replication and transcr…

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