Sex-stratified blood transcriptomic candidate biomarkers of multiple sclerosis identified by ensemble feature selection.

Aneta Polewko-Klim¹, Natalia Wawrusiewicz-Kurylonek²

¹Faculty of Computer Science, University of Bialystok, Ciołkowskiego 1M, Białystok, 15-245, Poland. Electronic address: anetapol@uwb.edu.pl.

²Department of Clinical Genetics, Medical University of Bialystok, Waszyngtona Str. 13, Białystok, 15-089, Poland. Electronic address: natalia.wawrusiewicz-kurylonek@umb.edu.pl.

PubMed DOI

Abstract

Sex-related differences in multiple sclerosis (MS), including variation in incidence, disease course, immune responses, and progression, suggest that sex influences disease-related molecular mechanisms. However, the identification of robust sex-specific molecular markers remains challenging due to data heterogeneity, high dimensionality, and limited sample size. This study aimed to identify candid…

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