Clinical, genomic, and spatial transcriptomic features of pancreatic adenosquamous carcinoma support subtype-specific therapeutic strategies.

S Daniel Haldar¹, Meredith Wetzel², Jiayun Lu³, Jae W Lee⁴, Hassan Sinan⁵, Christopher D Jakubowski⁶, Fen Saj⁷, Dean Pavlick⁸, Ryon P Graf⁹, Julia Quintanilha¹⁰, Gerald Li¹¹, Jerry Mitchell¹², Jeffrey S Ross¹³, Anirban Maitra¹⁴, Milind Javle¹, Shubham Pant¹, Hao Wang², Richard Burkhart¹⁵, Daniel A Laheru¹⁶, Elizabeth M Jaffee¹⁵, Elana J Fertig¹⁷, Elizabeth D Thompson², Dimitrios N Sidiropoulos², Luciane T Kagohara¹⁵, Nilofer S Azad⁴

¹The University of Texas MD Anderson Cancer Center Houston, TX United States.

²Johns Hopkins Medicine Baltimore United States.

³Johns Hopkins University United States.

⁴Johns Hopkins University Baltimore, Maryland United States.

⁵Icahn School of Medicine at Mount Sinai New York United States.

⁶Montefiore Einstein Comprehensive Cancer Center Bronx, NY United States.

⁷The University of Texas MD Anderson Cancer Center Houston United States.

⁸Foundation Medicine, Inc Boston, MA United States.

⁹Foundation Medicine San Diego, CA United States.

¹⁰Foundation Medicine Cambridge, MA United States.

¹¹Foundation Medicine (United States) Cambridge, MA United States.

¹²Foundation Medicine (United States) Boston, MA United States.

¹³SUNY Upstate Medical University Syracuse, NY United States.

¹⁴NYU Langone Health Houston United States.

¹⁵Johns Hopkins University Baltimore, MD United States.

¹⁶Sidney Kimmel Comprehensive Cancer Center Baltimore, MD United States.

¹⁷University of Maryland, Baltimore Baltimore, Maryland United States.

PubMed DOI

Abstract

PURPOSE: Pancreatic adenosquamous carcinoma (ASQ) is a rare variant with poorly defined clinical and molecular features compared to conventional pancreatic ductal adenocarcinoma (PDAC). This study aimed to characterize the clinical outcomes, genomic landscape, and spatial transcriptomic architecture of ASQ. EXPERIMENTAL DESIGN: We retrospectively evaluated clinicopathologic features, treatment pa…

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