An epigenetic view of anxiety disorders, one cell type at a time.

Klara Mareckova¹, Yuliya S Nikolova²

¹Brain and Mind Research Programme, Central European Institute of Technology, Masaryk University (CEITEC MU), Brno, Czech Republic; First Department of Neurology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Electronic address: klara.mareckova@ceitec.muni.cz.

²Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

PubMed DOI

Abstract

A recent publication by Ingram et al. revealed the importance of cellular precision in psychiatric epigenetics. Using cellular deconvolution, the authors showed that anxiety is associated with cell type-specific DNA methylation signatures reflecting stress, inflammation, and accelerated aging. These findings have critical implications for neuroscience studies aiming to bridge the gap between the p…

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