Peer-Reviewed Publication
BMJ2026;394e100216.August 11, 2026Journal Article
Evidence based interventions for bipolar disorder across phases and age groups: living umbrella review, evaluation, analysis, and communication hub (U-REACH) project.
Michele De Prisco1,2,3,4, Vincenzo Oliva1,2,3,4,5, Alessandro Miola6,7, Michele Fornaro8, Elena Dragioti9, Giovanni Croatto6, Andre F Carvalho10, Michael Berk10, Katerina Nikolitch11,12,13, Gayatri Saraf11,13,14, Lakshmi N Yatham15, Kamyar Keramatian15, Risa Shorr16, Mark A Frye7, Balwinder Singh7, Damir Krinitski17, Mikkel Højlund18,19,20, Alessandro Serretti21,22, Giuseppe Fanelli5,23, Fabiano A Gomes24,25, Anne Sofie Hansen26,27, Rene Ernst Nielsen26,27, Paolo Fusar-Poli28,29,30, Pasquale Paribello31,32, Mirko Manchia31,32,33, Anees Bahji34,35,36,37, Gustavo Vazquez38, Spyridon Siafis39,40, Stefan Leucht39,40, Ayşegül Yildiz41,42, Richard Delorme43,44, Ayal Schaffer45,46, Brendon Stubbs47,48,49, Ruby Rubaiyat50, Eduard Vieta1,2,3,4, Christoph U Correll51,52,53,54, David Moher55,56, Samuele Cortese57,58,59,60,61, Jess G Fiedorowicz11,12,13,14,55, Joaquim Radua1,3,4, Corentin J Gosling43,57,62, Marco Solmi63,12,13,51
1Department of Medicine, Faculty of Medicine and Health Sciences, Institute of Neurosciences, University of Barcelona, Barcelona, Spain.
2Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, Barcelona, Spain.
3Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain.
4Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.
5Department of Biomedical and Neuromotor Science, University of Bologna, Bologna, Italy.
6Department of Neuroscience, University of Padova, Padua, Italy.
7Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
8Section of Psychiatry, Department of Neuroscience, Reproductive Science, and Odontostomatology Federico II University of Naples, Naples, Italy.
9Scientific Laboratory of Psychology and Person-Centered Care, Department of Nursing, School of Health Sciences, University of Ioannina, Ioannina, Greece.
10Deakin University School of Medicine, Geelong, VIC, Australia.
11University of Ottawa, Department of Psychiatry, Ottawa, ON, Canada.
12The Ottawa Hospital, Department of Mental Health, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada.
13Ottawa Hospital Research Institute (OHRI) Neurosciences Program, Ottawa, ON, Canada.
14The Royal's Institute of Mental Health Research, Ottawa, ON, Canada.
15Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
16Library Services, The Ottawa Hospital, Ottawa, ON, Canada.
17University Hospital of Psychiatry Zurich, Clinic for Child and Adolescent Psychiatry and Psychotherapy, Zurich, Switzerland.
18Department of Psychiatry Aabenraa, Mental Health Services in the Region of Southern Denmark, Aabenraa, Denmark.
19Clinical Pharmacology, Pharmacy, and Environmental Medicine, Department of Public Health, University of Southern Denmark, Odense, Denmark.
20Child and Adolescent Mental Health Centre, Mental Health Services Capital Region of Denmark, Copenhagen, Denmark.
21Department of Medicine and Surgery, Kore University of Enna, Enna, Italy.
22Oasi Research Institute-IRCCS, Troina, Italy.
23Department of Human Genetics, Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, Netherlands.
24Mood Disorders Treatment and Research Clinic, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.
25Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada.
26Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark.
27Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
28University of Pavia, Department of Brain and Behavioural Sciences, Pavia, Italy.
29OASIS service, South London and Maudsley NHS Foundation Trust, London, UK.
30Early Psychosis: Interventions and Clinical-detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
31Section of Psychiatry, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
32Unit of Clinical Psychiatry, Department of Medical Specialties, University Hospital Agency of Cagliari, Cagliari, Italy.
33Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
34Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
35Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
36Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
37The Mathison Centre for Mental Health Research and Education, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
38Department of Psychiatry, Queen's University, Kingston, ON, Canada.
39Technical University of Munich, TUM School of Medicine and Health, Department of Psychiatry and Psychotherapy, TUM University Hospital, Munich, Germany.
40German Centre for Mental Health (DZPG), partner site München/Augsburg, Munich, Germany.
41Mind and Longevity Saglik-Danismanlik, Izmir, Turkey.
42Depression and Bipolar Disorder Foundation, Izmir, Turkey.
43Child and Adolescent Psychiatry Department, Robert Debré Hospital, APHP, Paris, France.
44University of Paris Cité, Paris, France.
45Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
46Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
47Clinical Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
48Comprehensive Centre for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
49Division of Psychology and Mental Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.
50Hatching Ideas Lab, Ottawa Hospital Research Institute (OHRI) Neurosciences Program, Ottawa ON, Canada.
51Charité Universitätsmedizin Berlin, Department of Child and Adolescent Psychiatry, Berlin, Germany.
52Department of Psychiatry, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.
53The Zucker Hillside Hospital, Northwell Health, New York, NY, USA.
54German Centre for Mental Health (DZPG), partner site Berlin, Berlin, Germany.
55School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
56Centre for Journalology, Methodological and Implementation Research Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
57Developmental EPI (Evidence synthesis, Prediction, Implementation) Lab, Centre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
58Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK.
59Hampshire and Isle of Wight Healthcare, NHS Foundation Trust, Southampton, UK.
60Hassenfeld Children's Hospital at NYU Langone, New York University Child Study Center, New York, NY, USA.
61DiMePRe-J-Department of Precision and Rigenerative Medicine-Jonic Area, University of Bari (Aldo Moro), Bari, Italy.
62DysCo Laboratory, Université Paris Nanterre, Nanterre, France.
63University of Ottawa, Department of Psychiatry, Ottawa, ON, Canada msolmi@toh.ca.
Abstract
OBJECTIVES: To systematically evaluate the certainty of evidence for treatment strategies across age groups and mood phases in bipolar disorder, and develop an open access web platform to facilitate shared decision making.
DESIGN: Living umbrella review, evaluation, analysis, and communication hub (U-REACH) project.
DATA SOURCES: PubMed, PsycInfo, and Cochrane library databases, from inception t…
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