Peer-Reviewed Publication
Geroscience2026August 10, 2026Journal Article
Preserving joint healthspan in knee osteoarthritis: a geroscience-guided review of non-surgical therapies and genicular artery embolization.
Ákos Bérczi1,2, Fanni É Szablics1, Dóra Hámori1, Edit Dósa3,4, Gergő Merkely5, Mark Little6, Zoltán Ungvári7, György Nagy8,9,10
1Department of Interventional Radiology, Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, 1122, Hungary.
2Hungarian Vascular Radiology Research Group, Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, 1122, Hungary.
3Department of Interventional Radiology, Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, 1122, Hungary. dosa.edit@semmelweis.hu.
4Hungarian Vascular Radiology Research Group, Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, 1122, Hungary. dosa.edit@semmelweis.hu.
5Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
6Department of Radiology, Royal Berkshire NHS Foundation Trust, Royal Berkshire Hospital, Levels 1 and 2, Centre Block, Craven Road, Reading, , Berkshire, RG1 5AN, UK.
7Department of Neurosurgery, Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, University of Oklahoma Health Sciences Center, BRC 1315, 975 NE 10Th Street, Oklahoma City, OK, 73104, USA.
8Department of Rheumatology and Immunology, Semmelweis University, Frankel Leó Street 25-29, Budapest, 1023, Hungary.
9Heart and Vascular Center, Semmelweis University, Városmajor Street 68, Budapest, 1122, Hungary.
10Department of Genetics, Cell and Immunobiology, Semmelweis University, Nagyvárad Square 4, Budapest, 1089, Hungary.
Abstract
Knee osteoarthritis (KOA) is a leading cause of late-life pain, mobility loss, and disability, and is increasingly recognized as a phenotype-dependent manifestation of joint aging rather than a purely mechanical disorder. Cellular senescence, inflammaging, mitochondrial dysfunction, synovial inflammation, vascular remodeling, and impaired repair capacity converge to shape KOA symptoms and progress…
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