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Clin Chem Lab Med2026August 7, 2026Journal Article

Unified definition of integrated diagnostics: a position statement of the EFLM.

Jochen K Lennerz1, Fabio Del Ben2, Albrecht Stenzinger3, Katrin B M Frauenknecht4, Anna Carobene5, Nino Berishvili6, João Tiago Guimarães7, Luis Martí-Bonmatí8, Reinhard Buettner9, Verena Haselmann10, Daniele Regge11, Roberto Salgado12,13, Mario Plebani14, Pieter Vermeersch15, Sergio Bernardini16, Janne Cadamuro17, Yale Tung-Chen18, Norman Zerbe19,20,21,22,23,24,25, Ian A Cree26, Michael Neumaier27, Regina Beets-Tan28,29,30, Pilar Fernandez Calle31, Miriam A Bredella32, Tomris Ozben33,34,
1Natera, Austin, TX, USA.
2CRO Aviano, National Cancer Institute, IRCCS, Aviano, Italy.
3Institute of Pathology, Heidelberg University Hospital; Center for Personalized Medicine (ZPM), German Cancer Consortium (DKTK), Heidelberg, Germany.
4Institute of Neuropathology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
5Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
6National Center for Disease Control and Public Health (NCDC), Tbilisi, Georgia.
7Faculdade de Medicina, Universidade Do Porto, Porto, Portugal.
8Department of Medical Imaging, La Fe Polytechnic and University Hospital, Valencia, Spain.
9Institute of Pathology, University Hospital Cologne, Cologne, Germany.
10Institute of Clinical Chemistry, University Hospital Mannheim (Universitätsmedizin Mannheim), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
11Imaging and Data Processing Lab (IDP-Lab), Candiolo Cancer Institute, Candiolo-Torino; University of Torino, School of Medicine, Torino, Italy.
12Division of Research, Peter MacCallum Cancer Centre, GZA-ZNA Ziekenhuizen, Melbourne, Australia.
13Department of Pathology, Antwerp, Belgium.
14Department of Medicine-DIMED, University of Padova, Padova, Italy.
15Clinical Department of Laboratory Medicine, University Hospitals, Leuven, Belgium.
16Department of Integrated Diagnostics, University of Tor Vergata Hospital, Rome, Italy.
17Department of Laboratory Medicine, University Hospital Salzburg/Paracelsus Medical University, Salzburg, Austria.
18Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain.
19Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
20Institute of Medical Informatics, Charité - Universitätsmedizin Berlin, Berlin, Germany.
21European Society of Digital and Integrative Pathology (ESDIP), Lisboa, Portugal.
22Asian Society of Digital Pathology (ASDP), Singapore, Singapore.
23Latin American Society of Digital Pathology (LASDIP), Santiago de Chile, Chile.
24African Society of Digital Pathology (AFSDP), Duba, UAE.
25EMPAIA - Ecosystem for Pathology Diagnostics with AI Assistance, Berlin, Germany.
26Institute of Ophthalmology, University College London, London, UK.
27Dept. of Cardiology, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.
28GROW - Research Institute for Oncology & Reproduction, Maastricht University, Maastricht, Netherlands.
29Maastricht Radiation Oncology, Institute, Maastricht, Netherlands.
30Department of Laboratory Medicine, Hospital Universitario La Paz, Madrid, Spain.
31EFLM Science Division Executive Committee, Milano, Italy.
32Department of Radiology, Clinical and Translational Science Institute, NYU Grossman School of Medicine, NYU Langone Health, New York, USA.
33Department of Clinical Biochemistry, Faculty of Medicine, Akdeniz University, Antalya, Türkiye.
34University of Modena and Reggio Emilia, Medical Faculty, Clinical and Experimental Medicine, Ph.D. School, Modena, Italy.
PubMed DOI

Abstract

Integrated diagnostics is an emerging multidisciplinary model of care that integrates traditionally siloed domains, including pathology, radiology, genomics, and laboratory medicine, into a coordinated framework designed to improve diagnostic accuracy, treatment selection, and clinical outcomes. In this position statement, the EFLM Integrated Diagnostics Committee proposes a concise and operationa…

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