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Peer-Reviewed Publication
Clin Sci (Lond)2026;140(9):1849-1872.September 9, 2026Journal Article

A novel tsRNA, 5'tiRNA-GluCTC, mediates cardiomyocyte-fibroblast cross-talk to promote cardiac fibrosis in restrictive cardiomyopathy.

Xiaohui Xu1, Xiaoli Yan1, Shan Huang1, Maidina Aini1, Lingjuan Liu1, Jiajin Li1, Jinpeng Zhang1, Fujian Lu2, Peng Gao1, Tiewei Lv1, Xupei Huang3, Jun Cao4, Bo Pan1, Jie Tian1
1Department of Cardiology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Key Cardiovascular Specialty, Chongqing Municipal Health Commission Key Laboratory of Children's Vital Organ Development and Diseases, Chongqing 401122, China.
2Department of Cardiology, Zhongshan Hospital, Institutes of Biomedical Sciences, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.
3Department of Biomedical Science, Charlie E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, U.S.A.
4College of Chemistry and Life Science, Beijing university of Technology, China.
PubMed DOI

Abstract

Restrictive cardiomyopathy (RCM) is characterized by pronounced cardiac fibrosis (CF), leading to ventricular stiffening and diastolic dysfunction. While cardiomyocyte (CM) mutations are known triggers, the mechanisms initiating profibrotic signaling remain elusive. This study investigates the role of CM-derived exosomes and specific transfer RNA-derived small RNAs (tsRNAs) in this pathogenic inte…

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