Nucleoporin 98 Rearrangements in Acute Leukemia: A Genomic Landscape Study.

Osama Batayneh¹, Natalie Danziger², Mahmoudreza Moein³, Nour S Naji³, Dean Pavlick², Jeffrey S Ross^2,4, Chelsea Marcus², Caleb Ho², Teresa Gentile¹, Zheng Zhou⁵, Lincoln W Pasquina²

¹Division of Hematology/Oncology, Department of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.

²Foundation Medicine, Inc., Boston, Massachusetts, USA.

³Department of Medicine, SUNY Upstate Medical University, Syracuse, New York, USA.

⁴Department of Pathology, SUNY Upstate Medical University, Syracuse, New York, USA.

⁵City of Hope, National Cancer Center, Duarte, California, USA.

PubMed DOI

Abstract

Nucleoporin 98 rearrangements (NUP98re) occur in a wide range of hematologic malignancies including acute leukemias with a variety of fusion partners. NUP98re is associated with adverse prognosis, especially in children. We aimed to better understand the genomics of acute leukemias with NUP98re including fusion partners and co-occurring genomic alterations (GA). Results from 5905 patients with acu…

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