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Peer-Reviewed Publication
Curr Probl Cardiol2026;103402.July 19, 2026Journal Article

Clinical Manifestations, Diagnosis, and Therapeutic Advances in May-Thurner Syndrome: A Comprehensive Literature Review.

Francis Ezekwueme1, Chidubem Ezenna2, Andrew Ndakotsu3, Abdulraheem Eniola Hassan4, George Akyea Blankson5, Charles Agwuegbo6, Chukwudumaga Iloh7, Ekeneilichukwu Nnadi8, Tamunoinemi Bob Manueli9
1Department of Medicine, University Of Pittsburgh Medical Center, McKeesport, PA. Electronic address: ezekwuemef@upmc.edu.
2Department of Medicine, University of Massachusetts - Baystate Medical Center, Springfield, Massachusetts, USA, 759 Chestnut Street, Springfield, MA 01199, USA. Electronic address: Cezenna349@gmail.com.
3Department of Medicine, MedStar Health Union Memorial Hospital, 201 E. University Pkwy. Baltimore, MD 21218. Electronic address: ninoskills@gmail.com.
4Department of Internal Medicine, Saint Peter's University Hospital 254 Easton Avenue, New Brunswick, NJ, 08901. Electronic address: hassaneniola85@yahoo.com.
5Department of Medicine, University Hospitals Cleveland Medical Center/Case Western Reserve University, 11100 Euclid Avenue, LKS-5029, Cleveland, OH 44106-5029. Electronic address: geoblanko@yahoo.com.
6Department of internal medicine, Southwest Healthcare, 31700 Temecula Parkway, Temecula, CA, 9259. Electronic address: chibuike.agwuegbo@gmail.com.
7Department of Engineering. Duke University, Durham, NC 27708. Electronic address: chukwudumaga.iloh@duke.edu.
8Department of Medicine. SUNY Downstate Health Sciences, 450 Clarkson Avenue, Brooklyn, NY 11203. Electronic address: Ekenedilichu.nnadi@gmail.com.
9University of Tennessee Health Science Center. Division of Cardiovascular Disease. 920 Madison Avenue, Suite 531, Memphis, TN 38163. Electronic address: Brieflybob@gmail.com.

Abstract

May-Thurner Syndrome (MTS), or iliac vein compression syndrome, is an underdiagnosed vascular condition where the left common iliac vein is compressed, typically by the right common iliac artery. This impairs venous outflow from the left lower extremity, leading to manifestations ranging from chronic venous insufficiency to acute deep vein thrombosis (DVT). Historically noted by Virchow and detail…

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