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Peer-Reviewed Publication
Intern Emerg Med2026July 8, 2026Journal Article

Real-world clinical evaluation of the Inflammatix TriVerity test for sepsis at the emergency department: an Acutelines study.

Michèle A Ter Voert1, Jingyi Lu2,3, Carolina Hincapié-Osorno3,4, Tamar J van der Aart3, Sanne Ter Horst3, Mehtap Ünal2,3, Martje Visser3, Raymond J van Wijk2, Jan Ter Maaten2,3, Natalie N Whitfield5, Purvesh Khatri6,7, Timothy E Sweeney5, Fredrike Blokzijl8, Jie Li3, Hjalmar R Bouma2,3,9
1Department of Acute Care, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands. m.a.ter.voert@umcg.nl.
2Department of Acute Care, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.
3Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
4Grupo de Investigación en Urgencias y Emergencias (GIURE), Universidad de Antioquia, Medellín, Antioquia, Colombia.
5Inflammatix, Inc, Sunnyvale, CA, 94085, USA.
6Institute for Immunity, Transplantation, and Infection, School of Medicine, Stanford University, Stanford, USA.
7Division of Computational Medicine, Department of Medicine, School of Medicine, Stanford University, Stanford, USA.
8Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
9Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
PubMed DOI

Abstract

Early sepsis recognition is challenging due to its heterogeneous presentations and limited rapid diagnostic and prognostic tools. The TriVerityTM Test, a high-multiplex host-response mRNA point-of-care test, supports clinical decision-making by estimating infection likelihood and illness severity. This study assesses TriVerity's accuracy in Dutch emergency department (ED) patients. Adult ED patien…

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