Peer-Reviewed Publication
Cell Signal2026;146112692.October 1, 2026Journal Article
Multiple regulatory roles of UNC93B1 in innate immunity.
Li Yi1, Yilin Li2, Xianhao Xiao3, Jialing Li4, Zhijun Yang5, Yanzhao Zhang6, Mengzhou Xue7, Chunfu Zheng8
1Department of Clinical Laboratory, Yiyang Central Hospital, Yiyang, Hunan, China.
2International Department, Shanghai Private Weiyu Middle School, China.
3Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China.
4Department of Family and Community Medicine, University of Illinois College of Medicine, Rockford, IL, USA.
5Shanghai Omics Biotechnology Co., Ltd, Shanghai, China.
6Department of Health Laboratory Technology, School of Public Health; Key Laboratory of Environmental Stress and Chronic Disease Control and Prevention, Ministry of Education, China Medical University, China. Electronic address: yanzhaozhang@cmu.edu.cn.
7Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450001, China. Electronic address: xuemengzhou@zzu.edu.cn.
8Department of Microbiology, Immunology, and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada. Electronic address: zheng.alan@hotmail.com.
Abstract
Uncoordinated 93 homolog B1 (UNC93B1) is a key innate immune regulator that affects the function of pattern recognition receptors. UNC93B1 is responsible for governing the intracellular trafficking and activation of nucleic acid-sensing TLRs. Recently, UNC93B1 was shown to regulate the cGAS/STING signaling pathway. As a result, UNC93B1 is a promising therapeutic target for various human diseases.…
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