Heated nebulization of ambroxol hydrochloride: engineering submicron aerosols for pulmonary drug delivery.

Yushi Tao¹, Ming Chu², Jingjing Deng², Jing Zhao², Wei Zhang³, Long Jin², Te Xu², Zehong Wu², Zhang Liu², Zhidong Liu⁴, Jin Lu⁵

¹Laboratory of Life and Health Sciences, Shenzhen Health Union Biotechnology Co., Ltd, Shenzhen 518103, China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

²Laboratory of Life and Health Sciences, Shenzhen Health Union Biotechnology Co., Ltd, Shenzhen 518103, China.

³Laboratory of Life and Health Sciences, Tianjin Ronxmed Biotechnology Co., Ltd, Tianjin 300399, China.

⁴School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. Electronic address: liuzhidong@tjutcm.edu.cn.

⁵Laboratory of Life and Health Sciences, Shenzhen Health Union Biotechnology Co., Ltd, Shenzhen 518103, China; Laboratory of Life and Health Sciences, Tianjin Ronxmed Biotechnology Co., Ltd, Tianjin 300399, China. Electronic address: 13842062044@163.com.

PubMed DOI

Abstract

Chronic respiratory diseases (CRDs) remain challenging to treat, largely due to the difficulty in delivering therapeutic agents to the deep lung. Ambroxol hydrochloride (AH), a widely used mucolytic agent that promotes mucus clearance, is indicated for conditions such as asthma, emphysema, and chronic bronchitis. This study reports the in vitro characterization of a heated medical nebulizer (MD6-H…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free Account Sign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.