Spinal cord reserve is associated with multi-dimensional clinical resilience in multiple sclerosis.

Stien Willems^1,2, Marie B D'hooghe^1,2,3, Jaume Sastre-Garriga⁴, Deborah Pareto⁵, Diana M Sima^6,7, Neus Mongay-Ochoa⁴, Laetitia Della Faille¹, Arno Liseune⁶, Guy Nagels^2,3,6,7, Ann Van Remoortel^1,7, Jeroen Van Schependom^3,7,8, Miguel D'Haeseleer^9,10,11

¹National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium.

²Department of Neurology, Universitair Ziekenhuis Brussel, Brussels, Belgium.

³NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

⁴Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

⁵Neuroradiology Section, Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

⁶Icometrix, Leuven, Belgium.

⁷AIMS Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium.

⁸ETRO Department, Vrije Universiteit Brussel, Brussels, Belgium.

⁹National Multiple Sclerosis Center, Vanheylenstraat 16, 1820, Melsbroek, Belgium. miguel.dhaeseleer@mscenter.be.

¹⁰Department of Neurology, Universitair Ziekenhuis Brussel, Brussels, Belgium. miguel.dhaeseleer@mscenter.be.

¹¹NEUR Research Group, Center for Neurosciences, Vrije Universiteit Brussel, Brussels, Belgium. miguel.dhaeseleer@mscenter.be.

PubMed DOI

Abstract

OBJECTIVE: Spinal canal area (SCaA)-a proxy for maximal lifetime spinal cord growth-has recently been associated with concurrent disability and future worsening in multiple sclerosis (MS). Prior studies focused mainly on the Expanded Disability Status Scale (EDSS). This study evaluates whether SCaA also relates to broader clinical outcomes. METHODS: We performed a retrospective longitudinal study…

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