Probing electron pathways to multicopper oxidase copper centers reveals shortcut for enhancing oxygen reduction reaction.

Qiujuan Shen¹, Thelma Barnetche¹, Elise Courvoisier-Dezord¹, Alan Le Goff², Thierry Tron³, Alexandre Ciaccafava⁴

¹Aix Marseille Univ, CNRS, Centrale Med, ISM2 UMR 7313, 13397 Marseille, France.

²University Grenoble Alpes and CNRS, DCM UMR 5250, F-38000 Grenoble, France. Electronic address: alan.le-goff@univ-grenoble-alpes.fr.

³Aix Marseille Univ, CNRS, Centrale Med, ISM2 UMR 7313, 13397 Marseille, France. Electronic address: thierry.tron@univ-amu.fr.

⁴Aix Marseille Univ, CNRS, Centrale Med, ISM2 UMR 7313, 13397 Marseille, France. Electronic address: alexandre.ciaccafava@cnrs.fr.

PubMed DOI

Abstract

Directly connected to an electrode, high potential MCOs catalyse the oxygen reduction reaction (ORR) at low overpotential with high efficiency. MCOs contain two redox centers, a near surface-located mononuclear copper (T1) oxidising a substrate and a buried trinuclear copper center (TNC) reducing dioxygen to water. Which of the two copper centers is directly wired to the electrode during the bioel…

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