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Sci Rep2026May 16, 2026Journal Article

The relationship between objective and subjective cognitive performance and clinical and MRI disease burden in early multiple sclerosis.

Delphine Van Laethem1,2, Lars Costers3,4, Augusto Miravalle5, Enrique Alvarez6, Bennett Myers7, Aaron Boster8, Hanan Al Halawani9, Maarten Dewil10, Melissa Cambron11,12, Matthias Grothe13, Stijn Denissen3, Rebecca Bartz4, Diana Sima3,4, Annemie Ribbens4, Dirk Smeets3,4, Guy Nagels3,14,15
1AIMS Lab, Vrije Universiteit Brussel/UZ Brussel, Brussels, Belgium. Delphine.Van.Laethem@vub.be.
2Department of Physical and Rehabilitation Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium. Delphine.Van.Laethem@vub.be.
3AIMS Lab, Vrije Universiteit Brussel/UZ Brussel, Brussels, Belgium.
4icometrix, Leuven, Belgium.
5Rush University, Chicago, IL, USA.
6Rocky Mountain Multiple Sclerosis Center, University of Colorado, Aurora, CO, USA.
7DENT Neurologic Institute, Amherst, NY, USA.
8The Boster Center for Multiple Sclerosis, Columbus, OH, USA.
9Texas Neurology, Dallas, TX, USA.
10Department of Neurology, Imelda Hospital, Bonheiden, Belgium.
11AZ Sint-Jan Brugge, Brugge, Belgium.
12University of Ghent, Ghent, Belgium.
13Universitätsmedizin Greifswald, Greifswald, Germany.
14Neurology Department, Universitair Ziekenhuis Brussel, Brussels, Belgium.
15St. Edmund Hall, University of Oxford, Oxford, UK.
PubMed PMC DOI PDF

Abstract

Subjective cognitive performance in multiple sclerosis (MS) correlates weakly with objective performance, but is more strongly associated with depression. We aimed to identify symptoms and brain MRI volumes related to subjective and objective cognitive performance. 205 MS subjects, diagnosed within the last 15 years, completed the SymptoMScreen, patient-reported Expanded Disability Status Scale, N…

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