Peer-Reviewed Publication
Neuroimage Rep2026;6(2):100343.June 1, 2026Journal Article
Comparability of Centiloid values from [18F]flutemetamol scans using seven commercial and research software.
Ariane Bollack1,2, Adam J Schwarz1, Pierrick Bourgeat3,4, Vincent Doré3,4, Jurgen Mejan-Fripp3,4, Christopher Page1, Elena Bonke5, Lennart Thurfjell5, Michael Hass6, Will Balhorn6, Aaron Nelson6, Rachid Fahmi7, Niklas Mattsson-Carlgren8,9, Sebastian Palmqvist8,9, Erik Stomrud8,9, Ruben Smith8,9, Oskar Hansson8,10, Renaud La Joie11, Gill Farrar1
1GE HealthCare, Chalfont St Giles, United Kingdom.
2Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom.
3CSIRO, Australian e-Health Research Center, Brisbane, Australia.
4Austin Heath, Department of Molecular Imaging & Therapy, Melbourne, VIC, Australia.
5Combinostics Oy, Tampere, Finland.
6MIM Software Inc., Cleveland, OH, USA.
7Siemens Medical Solutions USA, Inc., Molecular Imaging, Knoxville, TN, USA.
8Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.
9Memory Clinic, Skåne University Hospital, Malmö, Sweden.
10Eli Lilly and Company, Indianapolis, IN, USA.
11University of California San Francisco School of Medicine, San Francisco, CA, USA.
Abstract
UNLABELLED: Quantification using the Centiloid (CL) scale has become a valuable information to consider when interpreting amyloid-PET images and is now implemented in several software packages. This work aims to assess the comparability of CL from [18F]flutemetamol scans derived using several research and commercial quantification pipelines.
METHODS: This analysis relies on three datasets: a test…
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