Post-vaccine inflammation tracking: validation of a novel individualized digital inflammatory biomarker relative to serum biomarkers.

Darpit Dave¹, Ryan Heumann^2,3, Stephan Wegerich⁴, Jadranka Sekaric⁴, Jaap Oostendorp⁵, Robert Paris⁵, Matthew P Ward^2,3, Steven R Steinhubl²

¹Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. darpit@purdue.edu.

²Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.

³Indiana University School of Medicine, Indianapolis, IN, USA.

⁴Prolaio, Inc., Chicago, IL, USA.

⁵Moderna Inc, Cambridge, MA, USA.

PubMed PMC DOI PDF

Abstract

Inflammatory changes play a central role in both diseases and therapeutic interventions. Wearables are a promising novel method for inflammation detection and tracking through identifying subtle, individualized physiologic changes. We evaluated a wearable-derived individualized digital biomarker, inflammatory multivariate change index (iMCI) against serum biomarkers and reactogenicity following va…

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