eVO2peak
CPET-level cardiopulmonary insight without the stress test, administered remotely during daily activities
Company profile
Company profile
Prolaio is a cardiovascular health technology company that has developed a clinical intelligence platform designed to transform heart care through continuous, high-density data collection and analysis. The company's platform integrates medical insights and data analytics to improve the efficiency, quality, and success probability of cardiovascular clinical development. Using clinical-grade wearable sensors, Prolaio captures physiologic data including pulse, respiration, activity, and electrocardiogram continuously during patients' daily lives, rather than relying on episodic clinic-based assessments. Data collected by mobile relay devices are securely streamed to Prolaio's cloud environment where proprietary AI-based algorithms analyze the information to generate measures of cardiovascular function and capacity. The company serves patients, healthcare providers, and clinical researchers across 22+ countries, with a particular focus on accelerating drug development and enabling precision cardiology. Prolaio has developed FDA-cleared algorithms including eVO2peak, which provides CPET-level cardiopulmonary insights remotely without requiring patients to complete strenuous exercise tests. The company was co-founded by Tassos Gianakakos and operates in partnership with Kardigan, a cardiovascular therapeutics company, to create an integrated approach combining real-world data with drug development. Prolaio's mission is to transform real-world heart data into faster discovery and precision care for functional cures, with the ultimate goal of eradicating avoidable heart conditions.
Company description Prolaio official website
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01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Cloud Saas deployment with recorded integration context.
Company milestones
Recent FDA 510(k) clearance for eVO2peak algorithm; ISO 13485:2016 and MDSAP certification achieved; Strategic combination announced with Kardigan to create integrated heart health company
Partnerships
02 · Flagship portfolio
Selected source-backed Company products and the available commercial context.
CPET-level cardiopulmonary insight without the stress test, administered remotely during daily activities
Continuous remote cardiovascular monitoring platform for clinical research and patient care
03 · Research intelligence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
NPJ digital medicine · Apr 22, 2026
Danicamtiv, a Selective Agonist of Cardiac Myosin, for Dilated Cardiomyopathy: A Phase 2 Open-Label Trial.Journal of the American College of Cardiology · Dec 23, 2025
Continuous vital sign monitoring of acute Lassa fever using wearable biosensor devices in West Africa.Communications medicine · Jul 11, 2025
Development of a personalized digital biomarker of vaccine-associated reactogenicity using wearable sensors and digital twin technology.Communications medicine · Apr 13, 2025
Clinical Associations with Lenticulostriatal Vasculopathy (LSV) at Birth: A Case-Control Study.Children (Basel, Switzerland) · Feb 12, 2025
Lessons learnt from registration of biomedical research.Nature human behaviour · Jan 1, 2023
Clinical validation
NCT07420907 · Sponsor · RECRUITING
Regulatory
K252204 · 510k · Dec 16, 2025
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
Eliminating unnecessary travel through remote monitoring
Reduced trial costs and faster clinical decision making
Continuous monitoring vs episodic snapshots reduces variability and spot-checking errors
Keeping people out of hospital to eradicate avoidable heart conditions
05 · Leadership
Leadership profiles and professional links from the current Company record.
Tassos Gianakakos
Co-Founder
Derek Evans
General Manager
Greg Kurio
Head of Development Sciences
Chad Conkright
Chief Product Officer
Ewa Kleczyk
Chief Data + Analytics Officer
Joel Splan
Chief Privacy Officer
Stephan Wegerich
Chief Science Officer
Vinod Subramanian
Chief Information Officer
06 · Company updates
Recent articles published on Prolaio's official website.
07 · HAIC coverage
Health AI Central reporting that mentions this Company.
No HAIC coverage is currently linked to this Company.
08 · Official presence
Curated official destinations from the active Company record.
09 · Market pathway
Other active Companies in the same market, selected alphabetically from the HAIC directory.
Market context
Companies applying AI to cardiovascular disease detection, ECG/EKG analysis, heart failure management, cardiac imaging, arrhythmia detection, or cardiovascular risk assessment. Includes AI-powered cardiac diagnostics, non-invasive hemodynamic monitoring, and tools for early detection and personalized management of heart conditions.
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