Molecular Cancer Signal Localization in MCED Testing Minimizes Radiation and Imaging Burden Compared with Whole-body Imaging Approaches.

Mylynda Massart¹, Sana Raoof², Earl Hubbell³, Eric A Klein³

¹University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

²The Warren Alpert Medical School of Brown University, Providence, Rhode Island.

³GRAIL, Inc., Menlo Park, California.

PubMed PMC DOI PDF

Abstract

UNLABELLED: Efficient strategies for diagnostic evaluation of multicancer early detection (MCED) tests are needed to distinguish true-positive from apparent false-positive (FP) test results. Extending a previously published model, we compared 2 post-positive MCED test diagnostic evaluation strategies: a cancer signal origin (CSO)-guided approach with repeat MCED testing to resolve FPs (CSO-retest…

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