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Peer-Reviewed Publication
J Neurol2026;273(4)April 1, 2026Journal Article

Cross-sectional brain volumetric measures and disability outcomes in relapsing-remitting multiple sclerosis.

Michael T G Hayes1,2, Heidi N Beadnall3,4, Daniel Merlo5, Mastura Monif5,6, Chao Zhu5, Michael Barnett3,4, Katherine Buzzard7,8, Dana Horakova9, Tomas Kalincik10,11, Guy Laureys12, Elaine Lui13,14, Jeannette Lechner-Scott15,16, Ai-Lan Nguyen10,11, Francesco Patti17,18, Diana M Sima19, Dirk Smeets19, Manuela Vaneckova20, Wim Van Hecke19, Vincent Van Pesch21,22, Anneke van der Walt5,6, Helmut Butzkueven5,6
1Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, The Alfred Centre, Level 6, 99 Commercial Road, Melbourne, VIC, 3004, Australia. michael.hayes@monash.edu.
2Department of Neurology, Alfred Health, Melbourne, VIC, 3004, Australia. michael.hayes@monash.edu.
3Brain and Mind Centre, The University of Sydney, Sydney, NSW, 2050, Australia.
4Department of Neurology, Royal Prince Alfred Hospital, Sydney, NSW, 2050, Australia.
5Department of Neuroscience, School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, The Alfred Centre, Level 6, 99 Commercial Road, Melbourne, VIC, 3004, Australia.
6Department of Neurology, Alfred Health, Melbourne, VIC, 3004, Australia.
7Department of Neurology, Box Hill Hospital, Box Hill, VIC, 3128, Australia.
8Department of Neurosciences, Eastern Health Clinical School, Monash University, Box Hill, VIC, 3128, Australia.
9Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, 121 08, Prague, Czech Republic.
10Clinical Outcomes Research Unit (CORe), Department of Medicine, University of Melbourne, Melbourne, VIC, 3010, Australia.
11Neuroimmunology Centre, Royal Melbourne Hospital, Melbourne, VIC, 3000, Australia.
12Department of Neurology, Ghent University Hospital, 9000, Ghent, Belgium.
13Department of Medical Imaging, Royal Melbourne Hospital, Melbourne, VIC, 3050, Australia.
14Department of Radiology, University of Melbourne, Melbourne, VIC, 3010, Australia.
15University of Newcastle, Newcastle, NSW, 2308, Australia.
16Department of Neurology, John Hunter Hospital, Newcastle, NSW, 2305, Australia.
17Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", University of Catania, 95124, Catania, Italy.
18Azienda Ospedaliero-Universitaria Policlinico "G. Rodolico-San Marco", 95123, Catania, Italy.
19icometrix, 3012, Louvain, Belgium.
20Department of Radiology, First Faculty of Medicine, Charles University and General University Hospital, 121 08, Prague, Czech Republic.
21Department of Laboratory Medicine, Cliniques Universitaires Saint-Luc, 1200, Brussels, Belgium.
22Neurochemistry Unit, Institute of Neuroscience, Université Catholique de Louvain, 1348, Louvain-la-Neuve, Belgium.
PubMed PMC DOI PDF

Abstract

BACKGROUND: Automated cross-sectional magnetic resonance imaging (MRI) measures of brain volume are becoming available in clinical practice; however, their prognostic utility in multiple sclerosis remains unclear. OBJECTIVES: We investigated associations between cross-sectional brain and brain lesion volume measures and subsequent disability outcomes in relapsing-remitting multiple sclerosis (RRM…

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