Model-based evaluation of colorectal cancer screening effectiveness: three rounds of multitarget stool DNA testing versus one colonoscopy.

Michael Dore¹, Derek W Ebner², Vahab Vahdat³, Chris Estes³, A Burak Ozbay³, Victoria Foster³, Paul J Limburg³

¹Duke University Department of Medicine, Durham, NC, USA.

²Mayo Clinic Minnesota Division of Gastroenterology and Hepatology, Rochester, MN, USA.

³Exact Sciences Corporation, Madison, WI, USA.

PubMed DOI

Abstract

BACKGROUND: Several colorectal cancer (CRC) screening modalities are guideline-recommended in the United States but differ in screening interval and real-world adherence. Accordingly, single-round test performance may not reflect cumulative effectiveness over time. This study compared the 10-year longitudinal outcomes of two CRC screening strategies-triennial next-generation multitarget stool DNA…

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