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Peer-Reviewed Publication
JACC Heart Fail2026;14(7):103013.July 1, 2026Editorial

Using Days Alive and Out of Hospital as the Study Endpoint in Cardiovascular Heart Failure Clinical Trials.

Zachary R McCaw1, Stephanie Armbruster2, Lu Tian3, Brian L Claggett4, Garrett Fitzmaurice5, Alberto Foà6, Marc A Pfeffer4, Lee-Jen Wei7
1Insitro, South San Francisco, California, USA.
2Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
3Stanford University School of Medicine and Department of Statistics, Stanford University, Palo Alto, California, USA.
4Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
5Psychiatric Biostatistics Laboratory, McLean Hospital and Harvard Medical School, Boston, Massachusetts, USA.
6Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; Heart Failure and Transplant Unit-IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
7Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. Electronic address: wei@hsph.harvard.edu.
PubMed DOI

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