Company profile

insitro

Making Medicines Differently

Drug Discovery & DevelopmentSeries C stage

Company profile

About insitro

insitro is an AI therapeutics company that is redefining drug discovery and development by combining massive-scale cellular experiments with population-scale genetics. The company has built the Virtual Human™, a genetically anchored, causal AI engine built on the world's largest integrated multimodal corpus of human clinical and cellular data. This platform reveals how disease begins, progresses, and can be resolved by precisely identifying causal disease targets prior to candidate optimization. insitro's TherML™ is a modality-agnostic, AI-driven therapeutics design engine spanning small molecules, oligonucleotides, and complex biologics. By matching the best-fit modality to each target and indication, TherML shifts drug discovery from stochastic screening to predictive, adaptive engineering. The company has built a unique culture where life scientists, data scientists, engineers, and drug hunters work together to identify the most important questions, design and scale experiments, build models, and analyze results. insitro's approach integrates human data to understand which biological changes matter for disease with cellular data to determine what causes those changes, using AI to identify mechanisms consistent at both scales. The company is advancing multiple therapeutic programs including MASH, ALS, and metabolic diseases through strategic collaborations with major pharmaceutical companies.

Company description insitro official website

Mission. At insitro, we are building a different kind of drug company to bring better drugs faster to the patients who can benefit most. Through the power of machine learning (ML) and data at scale, we decode the complexities of biology to unlock transformative new medicines.

Primary marketDrug Discovery & Development
Commercial modelCommercial information available on request
Company presenceLinkedIn X
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01 · Operating footprint

Where the Company operates

Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.

Clinical focus

  • amyotrophic lateral sclerosis (ALS)
  • liver fat accumulation (MASLD)
  • metabolic diseases
  • metabolic dysfunction-associated steatohepatitis (MASH)
  • neurodegeneration
  • neuroscience
  • obesity
  • oncology

Who it serves

  • Pharma

Deployment & integration

On Premise · Other deployment with recorded integration context.

Geographic context

MarketsUnited Kingdom · United States
Company sourceOfficial website

Company milestones

Platform expansion

Acquired CombinAbleAI to complete full-stack modality-agnostic AI platform (TherML). Received $25M milestone payments from Bristol Myers Squibb for ALS target discovery. Completed first AI-enabled human genetics study of brown adipose tissue. Extended collaborations with Bristol Myers Squibb and Eli Lilly. Nominated new ALS targets. Presented MASH data at ADA 2026.

Partnerships

Recorded partners

  • Bristol Myers Squibb
  • Eli Lilly and Company
  • INSIGHT at Moorfields Eye Hospital

02 · Flagship portfolio

Products, workflows, and platform capabilities

Selected source-backed Company products and the available commercial context.

ChemML

AI platform for small molecule drug discovery integrating proprietary binding and functional assays

Platform · On PremiseCompany source

insitro ML-driven Platform

AI/ML platform integrating cellular and clinical data to redefine disease and accelerate drug discovery

Platform · On PremiseCompany source

POSH Platform

Pooled CRISPR screening platform with self-supervised deep learning for gene function inference

Platform · On PremiseCompany source

TherML

Full-stack, modality-agnostic AI platform for drug discovery and design across all major drug modalities

Platform · On PremiseCompany source

Virtual Human

Genetically anchored, causal AI engine revealing disease mechanisms and identifying causal disease targets

Platform · OtherCompany source

Virtual Human Platform

AI-driven platform for identifying key biological drivers and disease-modifying therapeutic targets

Platform · On PremiseCompany source

03 · Research intelligence

Research Intelligence evidence

Publications, preprints, clinical validation, and regulatory records in Evidence Position order.

Evidence position

Publications, clinical validation, and regulatory records connected to this Company appear here.

Research

Publications & preprints

No linked records are currently available.

Clinical validation

Clinical-trial records

No linked records are currently available.

Regulatory

Regulatory records

No linked records are currently available.

04 · Company-reported outcomes

Outcomes and case studies

Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.

15% body-weight reduction

BAT-01 knockdown in preclinical models through peripheral adipose beiging, preserving lean mass

Anti-fibrotic signal beyond liver-fat reduction

AI-discovered MASH candidate in preclinical studies

Eli Lilly and Company

Building AI models to predict in vivo pharmacokinetic properties of small molecules and advance metabolic disease treatments

Advanced machine learning models for small molecule in vivo PK behavior prediction now available in Lilly TuneLab

Bristol Myers Squibb

Discovery of novel ALS targets and advancement to next-generation therapies using insitro's AI platforms

$25 million in milestone payments received for achievement of discovery milestones and selection of first novel genetic target for ALS

INSIGHT at Moorfields Eye Hospital

Collaboration to expand research in neurodegeneration using world's largest bioresource of eye images as basis for AI foundation model

Access to world's largest bioresource of eye images to boost drug discovery

05 · Leadership

Leadership team

Leadership profiles and professional links from the current Company record.

Stephen Meadows

Stephen Meadows

Associate Director, Administration | Executive Assistant to the CEO

LinkedIn
Casey Chance

Casey Chance

Staff Software Engineer

LinkedIn

Eddie Ray Watts

Vice President of High-Throughput Chemistry

LinkedIn
Heiko Runz

Heiko Runz

Vice President for Neuroscience/Genetics

LinkedIn

06 · Company updates

Updates from insitro

Recent articles published on insitro's official website.

07 · HAIC coverage

Coverage and analysis

Health AI Central reporting that mentions this Company.

No HAIC coverage is currently linked to this Company.

08 · Official presence

Company sources and channels

Curated official destinations from the active Company record.

09 · Market pathway

Additional Companies in this Market

Other active Companies in the same market, selected alphabetically from the HAIC directory.

Market context

Drug Discovery & Development

Companies using AI, machine learning, or computational biology to discover new drug candidates, identify drug targets, predict drug efficacy, or accelerate pharmaceutical development. Includes both small molecule and biologics development, precision oncology drug discovery, and AI-driven target identification and molecule design.

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10 · Pro research

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Expanded Company research is in development.

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Deeper Company research is coming soon.

Pro Research will introduce expanded technical context, linked evidence analysis, and comparative Company research.

ResearchEvidence analysis

Linked research, clinical, and regulatory source pathways.

CompanyTechnical context

Expanded product, deployment, integration, and partnership research.

MethodSource & review record

Record-level provenance and review context.

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