LP-184
Novel synthetically lethal molecule targeting DNA damage repair deficient cancers
Company profile
Company profile
Lantern Pharma Inc. is a publicly-traded, clinical-stage biopharmaceutical company focused on transforming oncology drug development through artificial intelligence and precision medicine. The company operates at the intersection of AI, genomics, and machine learning to deliver targeted cancer therapies to the right patients with significantly reduced development costs and timelines. At the core of Lantern's approach is RADR® (Response Algorithm for Drug Positioning & Rescue), a proprietary AI-powered platform that analyzes over 200 billion oncology-specific data points using more than 200 advanced machine learning algorithms. The platform integrates transcriptome data, genomic data, and drug sensitivity information to predict patient responses, identify biomarkers, and stratify patient populations for clinical trials. This data-driven approach enables the company to rescue and revitalize promising oncology compounds while personalizing cancer treatments. Lantern's current portfolio includes three lead drug candidates and an ADC program spanning 12 cancer indications. The company has one lead product candidate (LP-300) in Phase 2 clinical testing through the Harmonic™ trial for never-smoker patients with non-small cell lung cancer, and Phase 1 programs for LP-184 (advanced solid tumors and glioblastoma) and LP-284 (non-Hodgkin's lymphoma). The company has also developed withZeta.ai, an AI research module that unifies clinical, molecular, and therapeutic information for rare and understudied cancers. Lantern Pharma manages an innovative patent portfolio with 95 issued patents and pending applications across 14 patent families.
Company description Lantern Pharma official website
Claim this profile to manage Company information and connect with the Health AI Central audience.
01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Cloud Saas · Other deployment with recorded integration context.
Company milestones
FDA authorization for Harmonic™ Phase 2 trial. August 2024: Announced preliminary patient data showing 86% clinical benefit rate. June 2026 (future date in content): Reported HARMONIC™ data on progression-free survival. Phase 1a enrollment completed for LP-184. Launched withZeta.ai AI research module. RADR® platform exceeded 200 billion data points.
Partnerships
No partners are currently listed.
02 · Flagship portfolio
Selected source-backed Company products and the available commercial context.
Novel synthetically lethal molecule targeting DNA damage repair deficient cancers
Novel synthetically lethal molecule for relapsed or refractory non-Hodgkin's lymphoma
Investigational drug for never smokers with non-small cell lung cancer
AI platform for blood-brain barrier penetration prediction
AI-powered platform for oncology drug development and patient response prediction
AI Co-Scientist for rare cancer drug discovery and development
03 · Research intelligence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
Cancer chemotherapy and pharmacology · Aug 12, 2026
A first-in-human phase 1a study of LP-184, a tumor-site activated novel alkylating agent, in patients with advanced solid tumors.Investigational new drugs · Jul 7, 2026
Chemotherapeutic induction of cytosolic single-stranded DNA accumulation sensitizes triple-negative breast cancer to immunotherapy.Journal for immunotherapy of cancer · Jun 29, 2026
Phase II Trial of LP-300 in Combination With Carboplatin and Pemetrexed in Never Smoker Patients With Relapsed Advanced Primary Adenocarcinoma of the Lung After Treatment With Tyrosine Kinase Inhibitors.Clinical lung cancer · Sep 1, 2025
Evaluation of Potency and Specificity of Cryptophycin-Loaded Antibody-Drug Conjugates.Chembiochem : a European journal of chemical biology · Jan 14, 2025
Clinical outcomes of DNA-damaging agents and DNA damage response inhibitors combinations in cancer: a data-driven review.Frontiers in oncology · Jan 1, 2025
Clinical validation
NCT05456256 · Sponsor · RECRUITING
Study of LP-184 in Patients With Advanced Solid TumorsNCT05933265 · Sponsor · ACTIVE NOT RECRUITING
Safety, Pharmacokinetics, and Clinical Activity of LP-284 in Adult Patients With Relapsed or Refractory Lymphomas and Solid TumorsNCT06132503 · Sponsor · RECRUITING
Irofulven in AR-targeted and Docetaxel-Pretreated mCRPC Patients With Drug Response Predictor (DRP®)NCT03643107 · Sponsor · COMPLETED
Evaluation of BNP7787 for the Prevention of Neurotoxicity in Metastatic Breast Cancer Patients Receiving Weekly PaclitaxelNCT00039780 · Sponsor · COMPLETED
Phase 3 Study of Tavocept Versus Placebo in Patients With Newly Diagnosed or Relapsed Advanced Primary Adenocarcinoma of the Lung Treated With Docetaxel or Paclitaxel Plus CisplatinNCT00966914 · Sponsor · COMPLETED
Regulatory
No linked records are currently available.
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
Initial patient cohort in Harmonic™ Phase 2 trial for LP-300
Biomarker-based trials compared to non-biomarker trials
LP-300 in EGFR Exon 21 L858R lung cancer, deepens with treatment duration
Treatment of never smokers with relapsed advanced primary adenocarcinoma of the lung (NSCLC) using LP-300 combination therapy
86% clinical benefit rate in initial patient cohort
05 · Leadership
Leadership profiles and professional links from the current Company record.
Panna Sharma
President & CEO
06 · Company updates
Recent articles published on Lantern Pharma's official website.
No Company updates are currently listed.
07 · HAIC coverage
Health AI Central reporting that mentions this Company.
No HAIC coverage is currently linked to this Company.
08 · Official presence
Curated official destinations from the active Company record.
09 · Market pathway
Other active Companies in the same market, selected alphabetically from the HAIC directory.
Market context
Companies using AI, machine learning, or computational biology to discover new drug candidates, identify drug targets, predict drug efficacy, or accelerate pharmaceutical development. Includes both small molecule and biologics development, precision oncology drug discovery, and AI-driven target identification and molecule design.
Explore the full market directory or compare this Company with additional active profiles.
View all Companies in this market10 · Pro research
Expanded Company research is in development.
Health AI Central Pro · Coming Soon
Pro Research will introduce expanded technical context, linked evidence analysis, and comparative Company research.
Linked research, clinical, and regulatory source pathways.
Expanded product, deployment, integration, and partnership research.
Record-level provenance and review context.