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Peer-Reviewed Publication
J Med Econ2026;29(1):467-480.December 1, 2026Journal Article

Clinical and economic benefits of combined genetic and genomic testing strategies to guide treatment decisions for patients with HR+/HER2- breast cancer in the US.

M Gouldson1, Q Le2, S Millen3, J Racz2, B Arrick2, D Hartzfeld2, B Heald2, S Eymere1, J-P De La O2, V Berdunov4, G Cuyun Carter2
1Putnam, London, UK.
2Exact Sciences, Madison, Wisconsin, USA.
3Exact Sciences, London, UK.
4ThermoFisher Scientific, London, UK.

Abstract

BACKGROUND: In the US, breast cancer is the most common female cancer. Personalized treatment strategies, informed by genomic assays and germline genetic testing (GGT), can optimize therapeutic decisions and improve patient outcomes along the hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer treatment pathway. PURPOSE: To evaluate the cost-ef…

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