Peer-Reviewed Publication
Commun Biol2026;9(1):225.January 13, 2026Journal Article
Large scale compound selection guided by cell painting reveals activity cliffs and functional relationships.
Maxime Sanchez1,2,3,4,5, Nicolas Bourriez1, Ihab Bendidi1, Ethan Cohen1, Ivan Svatko1,6, Elaine Del Nery7, Hamza Tajmouati5, Guillaume Bollot5, Laurence Calzone8,9,10, Auguste Genovesio11
1IBENS, Ecole Normale Supérieure, Université PSL, Paris, France.
2Institut Curie, Université PSL, Paris, France.
3INSERM, Paris, France.
4Mines ParisTech, Université PSL, Paris, France.
5Iktos, Paris, France.
6Université Paris Cité, IRD, Inserm, MERIT, Paris, France.
7Biophenics Laboratory, Institut Curie, PSL Research University, Department of Translational Research, Cell and Tissue Imaging Facility (PICT-IBiSA), Paris, France.
8Institut Curie, Université PSL, Paris, France. laurence.calzone@curie.fr.
9INSERM, Paris, France. laurence.calzone@curie.fr.
10Mines ParisTech, Université PSL, Paris, France. laurence.calzone@curie.fr.
11IBENS, Ecole Normale Supérieure, Université PSL, Paris, France. auguste.genovesio@ens.psl.eu.
Abstract
Traditional structure-based pre-screen compound selection relies on the assumption that chemical similarity implies similar biological activity. This paradigm narrows the exploration of chemical space and often fails to account for functional convergence, where structurally diverse compounds act through distinct targets to produce similar phenotypic effects. As a result, compounds with therapeutic…
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