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JACC Heart Fail2026;14(4):102831.April 1, 2026Editorial

Framework for Analytical Validation of DHT-Based Actigraphy and Signal Measures in HF Trials: The VALIDATE-HF Program.

Orhun Kose1, Aymen Sahal1, Guang K Zhang1, Elite Possik1, Mona Fiuzat2, Mitchell A Psotka3, David P Kao4, Elise Shalowitz4, Trejeeve Martyn5, Veraprapas Kittipibul2, Wei Ni6, Whittemore Tingley7, Vanja Vlajnic8, Steen Z Abildstrøm9, Martin Cowie10, Maulik Majmudar11, Tariq Ahmad12, Eric Leifer13, Marat Fudim14, Christopher M O'Connor3, Abhinav Sharma15
1DREAM-CV Lab, Research Institute, McGill University Health Centre, McGill University, Montreal, Quebec, Canada.
2Division of Cardiology, Duke University Medical Center, Durham, North Carolina, USA.
3Inova Schar Heart and Vascular, Falls Church, Virginia, USA.
4United States Colorado Center for Personalized Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
5Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
6Lilly Research Laboratory, Eli Lilly and Company, Indianapolis, Indiana, USA.
7Tenaya Therapeutics, San Francisco, California, USA.
8Bayer U.S., Whippany, New Jersey, USA.
9Novo Nordisk A/S, Søborg, Denmark.
10Imperial College London, London, United Kingdom.
11Biofourmis, Boston, Massachusetts, USA.
12Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.
13National Heart, Lung and Blood Institute, Bethesda, Maryland, USA.
14Duke Clinical Research Institute, Durham, North Carolina, USA.
15DREAM-CV Lab, Research Institute, McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Electronic address: abhinav.sharma@mcgill.ca.
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