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Peer-Reviewed Publication
bioRxiv2025November 12, 2025Journal Article

Proteome-wide in silico screening for human protein-protein interactions.

Ernst W Schmid1, Helen Zhu1, Eunjin Ryu1,2,3, Yang Lim1,4, Agata Smogorzewska5, Alan Brown1, Johannes C Walter1,2
1Department of Biological Chemistry & Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.
2Howard Hughes Medical Institute, Boston, MA 02115, USA.
3Present address: Department of Biology Education, College of Education, Seoul National University, Seoul 08826, Korea.
4Present address: Generate:Biomedicines, 101 South Street, Somerville, MA 02143.
5Laboratory of Genome Maintenance, Rockefeller University, 1230 York Avenue, New York, NY.
PubMed PMC DOI PDF

Abstract

Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational screen for human PPIs. First, a classifier called KIRC (Knowledge-Informed Rapid Classifier), trained on biological features, was used to rank all 200 million possible protein pairs in the human prot…

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