The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation and in vivo Regeneration.

Alexander D Brown^1,2, Annarita Scaramozza^1,3, Hanzhi Zhang¹, Samiha Mahin¹, Nivedita Suresh^1,4, Takeshi Tsusaka^1,5, Susan Eliazer^1,6, Xuhui Liu^1,2, Brian Feeley^1,2, Andrew S Brack¹

¹The Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Department of Orthopedic Surgery, University of California San Francisco, San Francisco, CA 94143, USA.

²San Francisco Veterans Affairs Health Care System, San Francisco, California, USA.

³Cellanome, Inc. 500 Lincoln Center Dr., Foster City, CA 94404.

⁴Rad AI, San Francisco, CA 94104, USA.

⁵Faculty of Pharmacy, Musashino University, Nishitokyo, Tokyo, Japan.

⁶Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND, USA.

PubMed PMC DOI PDF

Abstract

For efficient regeneration, muscle stem cells (MuSCs) transition out of quiescence through a series of progressively more activated states. During MuSC aging, transition through the earliest steps is the slowest and delayed, with the molecular regulators that govern this transition not well characterized. By analyzing the dynamic changes of MuSCs at the molecular (scRNA-Seq and Cell Painting) and…

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