Network Localization of Fatigue in Multiple Sclerosis.

Olli Likitalo^1,2,3, Jaakko Kungshamn^1,2,3, Albert Bellmunt-Gil¹, Silvia Tommasin^4,5, Abhineet Ojha⁴, Matias Viitala⁶, Juho Aaltonen^1,2,3, Jyrki Lötjönen⁷, Juha Koikkalainen⁷, Pauli Ylikotila³, Patrizia Pantano^4,8, Merja Soilu-Hänninen³, Juho Joutsa^1,2,3

¹Clinical Neurosciences, Turku Brain and Mind Center, University of Turku, Turku, Finland.

²Turku PET Center, Turku University Hospital, Turku, Finland.

³Neurocenter, Turku University Hospital, Turku, Finland.

⁴Human Neuroscience Department, Sapienza University of Rome, Rome, Italy.

⁵UniCamillus - International Medical University, Rome, Italy.

⁶StellarQ Ltd, Turku, Finland.

⁷Combinostics Ltd, Tampere, Finland.

⁸IRCCS Neuromed, Pozzilli, Italy.

PubMed PMC DOI PDF

Abstract

BACKGROUND: Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks associated with fatigue. METHODS: 38 MS patients with and 2…

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