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Peer-Reviewed Publication
Anal Chem2025;97(28):14964-14973.July 22, 2025Journal Article

Fast and Accurate Charge State Deconvolution of Protein Mass Spectra.

Kenneth R Durbin1, Matthew T Robey1, Joseph B Greer1, Ryan T Fellers1, Aaron O Bailey2
1Proteinaceous, Inc., Evanston, Illinois 60201, United States.
2AbCellera Biologics, Inc., Vancouver, British Columbia V5Y 1G6, Canada.
PubMed PMC DOI PDF

Abstract

Charge state deconvolution is essential for efficient and effective protein mass spectrometry analysis. High-quality mass profiling is necessary to determine which proteoforms are present in protein samples and their relative abundances. In the pursuit of a well-rounded deconvolution solution, we detail an iterative charge state deconvolution algorithm named kDecon that has been tuned to provide h…

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