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Peer-Reviewed Publication
Ann Pharmacother2026;60(3):258-264.March 1, 2026Journal Article

Hydrocortisone Dosing Frequency in Intensive Care Unit Patients With Septic Shock: A Comparison of 2 Regimens.

Abigail Danos1,2, Alyssa Lear3, Erin Roach4, Nicholas J Quinn1,5
1Atrium Health Carolinas Medical Center, Charlotte, NC, USA.
2University of Virginia Health, Charlottesville, VA, USA.
3Atrium Health Union, Monroe, NC, USA.
4Advocate Health, Charlotte, NC, USA.
5Department of Pharmacy, Carolinas Medical Center, Charlotte, NC, USA.
PubMed DOI

Abstract

BACKGROUND: In patients with septic shock, intravenous (IV) hydrocortisone is recommended when there is an ongoing vasopressor requirement. Guidelines recommend IV hydrocortisone 200 mg/day administered as a continuous infusion or 50 mg every 6 hours. To prevent waste during a hydrocortisone shortage and reduce cost, our institution implemented a dosing regimen of 100 mg every 12 hours. OBJECTIVE…

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