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Peer-Reviewed Publication
bioRxiv2025May 25, 2025Journal Article

Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice.

Chuanhai Zhang1, Dengbao Yang1, Hiroyuki Suzuki2, Jingxuan Chen3, Jingjing Wang4, Mengchen Ye5, Jin Zhou6, Qiyu Zeng4, Meijuan Bai1, Mei-Jung Lin1, Jeon Lee3, Hao Zhu4, Yujin Hoshida2, Xing Zeng1
1Department of Physiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
2Division of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
3Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center.
4Children's Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, Children's Research Institute Mouse Genome Engineering Core, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
5Xaira Therapeutics, Brisbane, CA, 94005, USA.
6Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
PubMed PMC DOI PDF

Abstract

Excessive lipid accumulation in hepatocytes, a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD), can lead to progressive liver damage. Understanding the molecular mechanisms governing lipid storage in hepatocytes is essential for identifying therapeutic targets to halt MASLD progression. Here, we show a pivotal role for the protein calsyntenin 3β (CLSTN3B) in promoting…

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