Rationale, design, and baseline characteristics of the virtual care to improve heart failure outcomes (VITAL-HF) trial.

Mirza S Khan¹, Andrew J Sauer¹, Cynthia L Green², Jaime McDermott³, Muhammad Shahzeb Khan⁴, Sunit-Preet Chaudhry⁵, Amir R Haghighat⁶, Mosi K Bennett⁷, Trejeeve Martyn⁸, Hirak Shah⁹, Ashul Govil¹⁰, Tom Stanis¹⁰, Nancy M Albert⁸, Adam D DeVore¹¹

¹Saint Luke's Mid America Heart Institute, Kansas City, MO; Healthcare Institute for Improvements in Quality, University of Missouri-Kansas City, Kansas City, MO.

²Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC.

³Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC.

⁴Baylor Scott and White Research Institute, Dallas, TX; The Heart Hospital, Plano, TX; Baylor College of Medicine, Temple, TX.

⁵Ascension - St. Vincent, Indianapolis, IN.

⁶Cardiovascular Institute of Northwest Florida, Panama City, FL.

⁷Allina Health Minneapolis Heart Institute, Minneapolis, MN.

⁸Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH.

⁹University of Kansas Medical Center, Kansas City, KS.

¹⁰Story Health, Cupertino, CA.

¹¹Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC; Duke Clinical Research Institute, Durham, NC. Electronic address: adam.devore@duke.edu.

PubMed DOI

Abstract

BACKGROUND: Among patients with heart failure (HF), guideline-directed medical therapy (GDMT) remains underutilized. Remote digital interventions may facilitate rapid initiation and uptitration of GDMT; however, potential benefits have not been evaluated in well-powered trials. The VITAL-HF (Virtual Care to Improve Heart Failure Outcomes) trial assessed the safety and efficacy of a remote, digital…

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