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Peer-Reviewed Publication
iScience2024;27(11):111123.November 15, 2024Journal Article

The secretory pathway in Tetrahymena is organized for efficient constitutive secretion at ciliary pockets.

Yu-Yang Jiang1,2, Santosh Kumar3, Aaron P Turkewitz1
1Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
2AbCellera Boston, Inc. 91 Mystic St, Arlington, MA 02474, USA.
3National Centre for Cell Science, NCCS Complex, Savitribai Phule Pune University Campus, Ganeshkhind Road, Pune, Maharashtra State 411007, India.
PubMed PMC DOI PDF

Abstract

In ciliates, membrane cisternae called alveoli interpose between the plasma membrane and the cytoplasm, posing a barrier to endocytic and exocytic membrane trafficking. One exception to this barrier is plasma membrane invaginations called parasomal sacs, which are adjacent to ciliary basal bodies. By following a fluorescent secretory marker called ESCargo, we imaged secretory compartments and secr…

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