Dye-less quantification of tissue perfusion by laser speckle contrast imaging is equivalent to quantified indocyanine green in a porcine model.

Garrett C Skinner^1,2, Mikael Marois², John Oberlin², Christopher J McCulloh², Steven D Schwaitzberg¹, Peter C Kim^3,4

¹Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Conventus, Buffalo, NY, USA.

²Activ Surgical Inc., Boston, MA, USA.

³Department of Surgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Conventus, Buffalo, NY, USA. pckim@buffalo.edu.

⁴Activ Surgical Inc., Boston, MA, USA. pckim@buffalo.edu.

PubMed DOI

Abstract

INTRODUCTION: Subjective surgeon interpretation of near-infrared perfusion video is limited by low inter-observer agreement and poor correlation to clinical outcomes. In contrast, quantification of indocyanine green fluorescence video (Q-ICG) correlates with histologic level of perfusion as well as clinical outcomes. Measuring dye volume over time, however, has limitations, such as it is not on-de…

Create a free account to keep reading

Free members get 10 full research views every month across publications, clinical trials, FDA clearances, adverse events, and NIH grants. No credit card required.

Create Free Account Sign In

Want unlimited research access? See Pro plans

Data Accuracy Notice: Research intelligence on Health AI Central is aggregated from public sources (PubMed, ClinicalTrials.gov, FDA, NIH, CMS, and others) and refreshed nightly. Classifications and derived metrics are produced by automated methods described in our Methodology. We recommend verifying critical data points against the primary sources before making decisions.