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Peer-Reviewed Publication
Diabetes Technol Ther2022;24(8):564-572.August 1, 2022Journal Article

Comparison of Insulin Dose Adjustments Made by Artificial Intelligence-Based Decision Support Systems and by Physicians in People with Type 1 Diabetes Using Multiple Daily Injections Therapy.

Revital Nimri1,2, Amir Tirosh2,3, Ido Muller4, Yael Shtrit4, Ivana Kraljevic5, Montserrat Martín Alonso6, Tanja Milicic7, Banshi Saboo8, Asma Deeb9, Athanasios Christoforidis10, Marieke den Brinker11, Lutgarda Bozzetto12, Andrea Mario Bolla13, Michal Krcma14, Rosa Anna Rabini15, Shadi Tabba16, Andriani Gerasimidi-Vazeou17, Giulio Maltoni18, Elisa Giani19, Idit Dotan2,20, Idit F Liberty21, Yoel Toledano22, Olga Kordonouri23, Natasa Bratina24, Klemen Dovc24, Torben Biester23, Eran Atlas4, Moshe Phillip1,2
1The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
2Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.
3Division of Endocrinology, Diabetes and Metabolism, Dalia and David Arabov Endocrinology and Diabetes Research Center, Sheba Medical Center, Tel Hashomer, Israel.
4DreaMed Diabetes Ltd., Petah Tikva, Israel.
5Department of Endocrinology and Diabetes, UHC Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
6Department of Pediatrics, Children's Endocrinology Unit, University Hospital of Salamanca, Spain.
7Clinic for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
8Dia Care Diabetes Care and Hormone Clinic, Ahmedabad, Gujarat, India.
9Pediatric Endocrine Division, Sheikh Shakhbout Medical City and Khalifa University, Abu Dhabi, United Arab Emirates.
101st Pediatric Department, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece.
11Division of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Antwerp University Hospital and University of Antwerp, Antwerpen, Belgium.
12Department of Clinical Medicine and Surgery, University of Naples "Federico II," Naples, Italy.
13Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy.
14Diabetes and Endocrinology Unit, Department of Internal Medicine, University Hospital Pilsen, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
15Department of Diabetology, Hospital Mazzoni, Ascoli Piceno, Italy.
16Department of Pediatric Endocrinology, Arnold Palmer Hospital for Children, Orlando, Florida, USA.
17Diabetes Center, A' Department of Pediatrics, P&A Kyriakou, Athens, Greece.
18Unit of Pediatrics, IRCCS-Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
19Department of Biomedical Sciences, Humanitas University, Milan, Italy.
20Rabin Medical Center, Institute of Endocrinology, Beilinson Hospital, Petach Tikva, Israel.
21Department of Medicine and Diabetes Unit, Soroka Medical Center, Faculty of Health Sciences, Beer Sheva, Israel.
22Division of Maternal Fetal Medicine, Helen Schneider Women's Hospital, Rabin Medical Center, Endocrinology Clinic, Petah Tikva, Israel.
23Diabetes Center for Children and Adolescents, Children's Hospital AUF DER BULT, Hannover, Germany.
24Department of Endocrinology, Diabetes and Metabolic Diseases, UMC-University Children's Hospital Ljubljana, and Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
PubMed DOI

Abstract

Objective: Artificial intelligence-based decision support systems (DSS) need to provide decisions that are not inferior to those given by experts in the field. Recommended insulin dose adjustments on the same individual data set were compared among multinational physicians, and with recommendations made by automated Endo.Digital DSS (ED-DSS). Research Design and Methods: This was a nonintervention…

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