AI Digital Twin
Real-time model of your body's unique metabolism for personalized metabolic health guidance
Platform · Cloud SaaSCompany source
Company profile
About Twin Health
Twin Health is a precision health company that combines artificial intelligence with personalized clinical care to address the root causes of metabolic conditions. The company's flagship AI digital twin technology creates a real-time model of each member's unique metabolism by analyzing data from continuous glucose monitors, wearables, and smart devices. This personalized approach enables members to reverse type 2 diabetes, achieve sustainable weight loss, and reduce or eliminate medications including GLP-1s and insulin. The platform serves individuals with metabolic conditions including type 2 diabetes, prediabetes, obesity, hypertension, and PCOS through employer-sponsored programs and health plans. Members receive support from a dedicated clinical care team including providers and coaches, along with daily AI-powered insights on food choices, activity, sleep, and stress management. Twin Health's approach addresses metabolic dysfunction—the root cause of many chronic conditions—rather than just managing symptoms. The company's outcomes are validated through peer-reviewed research published in leading medical journals including the New England Journal of Medicine Catalyst, Nature Scientific Reports, and JACC. Clinical results show 71% of members lowered A1C below 6.5% without glucose-lowering medications (except metformin), average weight loss of 27 pounds, 85% GLP-1 elimination, and 46% insulin elimination. Twin Health operates on a fully at-risk business model, partnering with employers and health plans to deliver measurable health improvements and cost savings.
Company description Twin Health official website
Primary marketMetabolic Health & Nutrition
Commercial modelCommercial information available on request
Company presenceOfficial website
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01 · Operating footprint
Where the Company operates
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Clinical focus
- High cholesterol
- Hypertension
- Inflammation
- Insomnia
- Insulin resistance
- Kidney dysfunction
- Liver dysfunction
- Obesity
- PCOS (Polycystic Ovary Syndrome)
- Prediabetes
- Type 2 diabetes
- Visceral fat
Who it serves
- Employers
- Health Plans
- Individual Members
Deployment & integration
Cloud Saas · Hybrid deployment with recorded integration context.
Geographic context
MarketsUnited States
Company sourceOfficial website
Company milestones
Platform expansion
Published Cleveland Clinic-led study in NEJM Catalyst (2025), published one-year outcomes study in Nature Scientific Reports (2024), received Validation Institute endorsement for Clinical Outcomes and Contractual Validity, published studies in JACC Advances and Endocrine Practice (2024)
Partnerships
Recorded partners
- Cleveland Clinic
02 · Flagship portfolio
Products, workflows, and platform capabilities
Selected source-backed Company products and the available commercial context.
Twin Health Metabolic Health Program
Comprehensive program for obesity, prediabetes, and type 2 diabetes management
Service · HybridCompany source
03 · Research intelligence
Research Intelligence evidence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Evidence position
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
Publications & preprints
Digital Twin Technology in Resolving Polycystic Ovary Syndrome and Improving Metabolic Health: A Comprehensive Case Study.AACE clinical case reports · Jan 1, 2025
One-year outcomes of a digital twin intervention for type 2 diabetes: a retrospective real-world study.Scientific reports · Oct 26, 2024
Digital Twin in Managing Hypertension Among People With Type 2 Diabetes: 1-Year Randomized Controlled Trial.JACC. Advances · Sep 1, 2024
Personalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control.Frontiers in endocrinology · Jan 1, 2024
Digital Twin-Enabled Personalized Nutrition Improves Metabolic Dysfunction-Associated Fatty Liver Disease in Type 2 Diabetes: Results of a 1-Year Randomized Controlled Study.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · Dec 1, 2023
Type 2 diabetes reversal with digital twin technology-enabled precision nutrition and staging of reversal: a retrospective cohort study.Clinical diabetes and endocrinology · Nov 15, 2021
Clinical validation
Clinical-trial records
No linked records are currently available.
Regulatory
Regulatory records
No linked records are currently available.
04 · Company-reported outcomes
Outcomes and case studies
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
71% lowered A1C below 6.5% without glucose-lowering medications (except metformin)
Cleveland Clinic study published in NEJM Catalyst 2025
27 lbs average weight loss
Cleveland Clinic study results 2025
85% GLP-1 elimination
Cleveland Clinic study results 2025
46% insulin elimination
Cleveland Clinic study results 2025
73% eliminated medications including injections
2025 group results
2.2 point drop in A1C among baseline A1C 8.0+
2025 group results
66% improved hypertension
2025 group results
81% improved cholesterol
2025 group results
78% improved visceral fat
2025 group results
89% reduced A1C below 7 after one year
Nature Scientific Reports study 2024
Members continue losing ~6% body weight after stopping GLP-1s
Active commercial members analysis
$8.0k annualized savings per member with at least one high-cost medication
Self-insured employer partner
$3.2M projected pharmacy savings annualized
Employer partner with members on high-cost medications
Cleveland Clinic
Evaluating AI-powered personalized precision treatment for type 2 diabetes care
71% lowered A1C below 6.5% without glucose-lowering medications (except metformin), 27 lbs average weight loss, 85% GLP-1 elimination, 46% insulin elimination
Self-insured employer partner
Metabolic health benefits program for employee population
19% eligible population activated within first year, $8.0k annualized savings per member with at least one high-cost medication, $3.2M projected pharmacy savings annualized
05 · Leadership
Leadership team
Leadership profiles and professional links from the current Company record.
No active leadership profiles are currently listed.
06 · Company updates
Updates from Twin Health
Recent articles published on Twin Health's official website.
07 · HAIC coverage
Coverage and analysis
Health AI Central reporting that mentions this Company.
No HAIC coverage is currently linked to this Company.
08 · Official presence
Company sources and channels
Curated official destinations from the active Company record.
09 · Market pathway
Additional Companies in this Market
Other active Companies in the same market, selected alphabetically from the HAIC directory.
Market context
Metabolic Health & Nutrition
Companies using AI to optimize metabolic health, provide personalized nutrition recommendations, or analyze metabolic responses to food for generally healthy or non-diabetic populations. Emphasizes wellness, performance optimization, and preventive health rather than management of a diagnosed disease.
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Expanded Company research is in development.
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Deeper Company research is coming soon.
Pro Research will introduce expanded technical context, linked evidence analysis, and comparative Company research.
Linked research, clinical, and regulatory source pathways.
Expanded product, deployment, integration, and partnership research.
Record-level provenance and review context.