Linked research, clinical, and regulatory source pathways.
Company profile
About Surescripts
Surescripts is the nation's leading health information network company, powering nationwide interoperability through trusted health intelligence sharing. The company connects 2.32 million healthcare professionals and provider organizations across the United States, processing over 30.5 billion network transactions annually. Surescripts enables secure, real-time exchange of clinical and medication data to inform and accelerate care decisions throughout the patient journey. The company's comprehensive product portfolio includes e-prescribing solutions that processed 2.64 billion prescriptions in 2025, Real-Time Prescription Benefit tools that delivered 1 billion responses to prescribers, medication history services providing 3.79 billion records, and electronic prior authorization platforms. Additional offerings include Clinical Direct Messaging for HIPAA-compliant care coordination, Electronic Benefit Verification, formulary management, and the Surescripts Health Information Network for clinical document exchange. Surescripts serves the entire healthcare ecosystem including EHR vendors, health plans, PBMs, pharmacies, health systems, life sciences companies, and specialty care providers. The company's network maintains 99.998% average uptime and has linked 5.97 billion clinical documents. Through its Network Alliance program, Surescripts brings together industry stakeholders to collaborate on solving major healthcare challenges. The company's solutions have demonstrated measurable impact, including 40% lower out-of-pocket costs for high-cost drug classes and improved medication adherence and care coordination nationwide.
Company description Surescripts official website
Primary marketPharmacy & Medication Management
Commercial modelCommercial information available on request
Company presenceOfficial website
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01 · Operating footprint
Where the Company operates
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Clinical focus
- chronic disease management
- controlled substances
- high-cost drug therapies
- medication management
- specialty medications
Who it serves
- EHR vendors
- Health Plans
- Health Systems
- Healthcare Analytics Vendors
- Life Sciences Companies
- Long-term & Post-Acute Care
- Patient Access Vendors
- PBMs
- Pharmacies
- Pharmacy Technology Vendors
- Specialty Pharmacies
Deployment & integration
Deployment information is currently being developed.
Recorded integration context: Cerner, EHR systems, Epic, Henry Schein MicroMD, PBM platforms, pharmacy management systems.
Geographic context
MarketsUnited States
Company sourceOfficial website
Company milestones
Platform expansion
Processed 30.5 billion network transactions in 2025, connected 2.32 million healthcare professionals and organizations, delivered 1 billion Real-Time Prescription Benefit responses, facilitated 104.3 million electronic case reports to public health agencies
Partnerships
Recorded partners
- Accredo
- CenterWell Pharmacy
- Network Alliance member organizations
- Sutter Health
02 · Flagship portfolio
Products, workflows, and platform capabilities
Selected source-backed Company products and the available commercial context.
No source-backed Company products are currently listed.
03 · Research intelligence
Research Intelligence evidence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Evidence position
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
Publications & preprints
Implementation outcomes of the Structured and Codified SIG format in electronic prescription directions.Journal of the American Medical Informatics Association : JAMIA · Oct 7, 2022
Comparing the variability of ingredient, strength, and dose form information from electronic prescriptions with RxNorm drug product descriptions.Journal of the American Medical Informatics Association : JAMIA · Aug 16, 2022
Access To E-Prescriptions And Related Technologies Before And After Hurricanes Harvey, Irma, And Maria.Health affairs (Project Hope) · Feb 1, 2019
Analysis of medication therapy discontinuation orders in new electronic prescriptions and opportunities for implementing CancelRx.Journal of the American Medical Informatics Association : JAMIA · Nov 1, 2018
Quality and Variability of Patient Directions in Electronic Prescriptions in the Ambulatory Care Setting.Journal of managed care & specialty pharmacy · Jul 1, 2018
A better way: leveraging a proven and utilized system for improving current medication reconciliation processes.The American journal of managed care · Mar 1, 2017
Clinical validation
Clinical-trial records
No linked records are currently available.
Regulatory
Regulatory records
No linked records are currently available.
04 · Company-reported outcomes
Outcomes and case studies
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
40% lower out-of-pocket cost for high-cost drug classes
Real-Time Prescription Benefit implementation
99.998% average network uptime
Network reliability
2.64 billion e-prescriptions filled in 2025
E-prescribing volume
1 billion Real-Time Prescription Benefit responses delivered in 2025
Benefit verification scale
3.79 billion medication histories delivered in 2025
Clinical intelligence sharing
104.3 million electronic case reports sent to public health agencies in 2025
Public health reporting
05 · Leadership
Leadership team
Leadership profiles and professional links from the current Company record.
No active leadership profiles are currently listed.
06 · Company updates
Updates from Surescripts
Recent articles published on Surescripts's official website.
No Company updates are currently listed.
07 · HAIC coverage
Coverage and analysis
Health AI Central reporting that mentions this Company.
No HAIC coverage is currently linked to this Company.
08 · Official presence
Company sources and channels
Curated official destinations from the active Company record.
09 · Market pathway
Additional Companies in this Market
Other active Companies in the same market, selected alphabetically from the HAIC directory.
Market context
Pharmacy & Medication Management
Companies using AI for medication optimization, pharmacy automation, drug pricing and access, medication adherence, polypharmacy management, or pharmacy workflow optimization. Includes platforms that help patients access affordable medications, tools that reduce medication errors, and AI systems that optimize drug regimens for complex patients.
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