OptimDBS
AI-powered deep brain stimulation planning platform
Company profile
Company profile
RebrAIn is a medical technology company specializing in precision brain targeting for functional neurosurgery, with a focus on deep brain stimulation (DBS) procedures for movement disorders. Founded as a spin-off of the University Hospital of Bordeaux and Inria after 10 years of academic research, the company was created by Professor Emmanuel Cuny, a neurosurgeon, and Professor Nejib Zemzemi, a researcher in applied mathematics at Inria. The company's flagship service is a supervised AI-driven solution that provides millimetric MRI-guided targeting for neurosurgical procedures. Using advanced algorithms and a health data exchange platform, RebrAIn identifies 18 anatomical landmarks per brain hemisphere to precisely locate treatment targets such as the subthalamic nucleus (STN) for Parkinson's Disease and the ventral intermediate nucleus (VIM) for Essential Tremor. The platform processes standard T1 MRI scans through a secure cloud-based system, delivering marked MRI images with target overlays within 24 hours. RebrAIn's technology aims to simplify and standardize neurosurgical procedures, potentially eliminating the need for intraoperative electrophysiology and enabling surgery under general anesthesia. This approach reduces procedure time, hospital stays, and patient trauma while maintaining high precision. The company serves neurosurgeons and hospital systems, with over 60 sites worldwide having adopted the technology and more than 1,000 targeting operations performed. RebrAIn operates with dual headquarters in France and the United States, positioning itself to serve both European and North American markets in the rapidly growing field of functional neurosurgery.
Company description RebrAIn, SAS official website
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01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
Cloud Saas deployment with recorded integration context.
Company milestones
2025/2026: Transatlantic expansion focusing on major US and European neurosurgery reference centers. Partnership with Worldwide Dystonia Research Center announced May 2026 to expand from STN/VIM targeting to GPi targeting for dystonia. Brand identity launch May 2026. Top partner centers by volume include Duke University, UVA, Pamplona, and UCLA.
Partnerships
02 · Flagship portfolio
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AI-powered deep brain stimulation planning platform
AI-driven MRI-guided brain targeting service for functional neurosurgery
03 · Research intelligence
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Research
No linked records are currently available.
Clinical validation
No linked records are currently available.
Regulatory
K242054 · 510k · Aug 12, 2024
OptimMRIK230150 · 510k · Jul 21, 2023
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
MRI-guided brain targeting for DBS surgery
Hospital affordability through reduced procedure time and hospital stays
Simplified surgical workflow
Less staff required in operating room
Eliminating need for intraoperative electrophysiology
From MRI upload to marked MRI delivery
High-volume neurosurgery center using Rebrain's AI-driven targeting service for DBS procedures
Top partner center by volume
Leading academic medical center implementing Rebrain's AI-guided brain targeting platform
Top partner center by volume
European reference center for functional neurosurgery using Rebrain's targeting services
Top partner center by volume
Major neurosurgery reference center utilizing Rebrain's targeting services for functional neurosurgery
Top partner center by volume
Global adoption of AI-driven brain targeting for DBS procedures in Parkinson's Disease and Essential Tremor
1,000+ targeting operations performed across 60+ sites; 20-30% cost savings; reduced hospital stay; reduced infection rate
05 · Leadership
Leadership profiles and professional links from the current Company record.
Emmanuel Cuny
Co-Founder, CMO & Chairman
Nejib Zemzemi
Co-Founder
06 · Company updates
Recent articles published on RebrAIn, SAS's official website.
07 · HAIC coverage
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08 · Official presence
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09 · Market pathway
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Market context
Companies developing surgical technologies enhanced by AI, including robotic surgical systems, AI-powered surgical assistance and navigation tools, autonomous surgical robotics, and surgical data and analytics platforms. Covers both the performance of surgery and the analysis of surgical outcomes and OR efficiency.
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