Proton
AI platform for medicinal chemistry to accelerate drug discovery
Company profile
Company profile
PostEra is building a modern 21st century biopharma that uses artificial intelligence to transform drug discovery. The company has developed Proton, an end-to-end machine learning platform that closes the Design-Make-Test cycle of medicinal chemistry. PostEra focuses on the chemistry stage of drug discovery, addressing the iterative three-step cycle of designing molecules, synthesizing them, and testing their properties. Their platform combines proprietary data with chemistry foundation models to design molecules that satisfy the competing properties required for drug candidates, while state-of-the-art synthesis planning ensures every designed molecule has a reliable synthetic route. PostEra advances small molecule programs through partnerships with leading biopharma companies while also developing its own internal pipeline. The company has established over $1 billion in AI partnerships with major pharmaceutical companies including Pfizer and Amgen, as well as the NIH. PostEra also launched and led COVID Moonshot, the world's largest open-science drug discovery effort. The company's mission is to accelerate medicinal chemistry and bring more cures to patients by making drug discovery faster, more optimized, and more successful.
Company description PostEra official website
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01 · Operating footprint
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Company milestones
January 2025: Expanded Pfizer collaboration to $610M. October 2023: Added Amgen collaboration bringing total AI partnerships to $1Bn. March 2024: Progress update on Pfizer AI Lab with third target nominated. December 2021: Established $260M AI Lab with Pfizer and closed $24M Series A.
Partnerships
02 · Flagship portfolio
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AI platform for medicinal chemistry to accelerate drug discovery
03 · Research intelligence
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Research
Journal of medicinal chemistry · Jun 11, 2026
Structure-Guided Discovery of Selective Polo-Like Kinase 3 Inhibitors.ACS medicinal chemistry letters · Jun 11, 2026
Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors.Nature communications · Oct 8, 2025
Structure-Activity Relationship Studies Towards Analogues of Pleconaril as Novel Enterovirus-D68 Capsid-Targeting Antivirals.bioRxiv : the preprint server for biology · Aug 12, 2025
Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease.bioRxiv : the preprint server for biology · Jun 20, 2025
Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor.bioRxiv : the preprint server for biology · Jun 17, 2025
Clinical validation
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Regulatory
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04 · Company-reported outcomes
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Pfizer AI Lab program reached first scientific milestone 40% faster than forecasted
AI Lab program for preclinical drug discovery leveraging machine learning for medicinal chemistry
First scientific stage gate achieved 40% faster than initially forecasted
05 · Leadership
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06 · Company updates
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07 · HAIC coverage
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08 · Official presence
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09 · Market pathway
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Market context
Companies using AI, machine learning, or computational biology to discover new drug candidates, identify drug targets, predict drug efficacy, or accelerate pharmaceutical development. Includes both small molecule and biologics development, precision oncology drug discovery, and AI-driven target identification and molecule design.
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