BioHive-2
Biopharma's most powerful supercomputer for AI drug discovery
Company profile
Company profile
Recursion is a pioneering TechBio company founded over a decade ago on the revolutionary idea of using cellular imaging and artificial intelligence to decode biology and transform drug discovery. The company has built the Recursion Operating System (Recursion OS), an advanced AI-driven drug discovery and development platform that leverages one of the largest fit-for-purpose proprietary biological and chemical datasets in the world—over 50 petabytes spanning phenomics, transcriptomics, proteomics, ADME, and de-identified patient data. Recursion's mission is to radically improve lives by addressing the massive 90% failure rate of traditional drug discovery through novel insights and precision design. The company's automated wet lab utilizes robotics and computer vision to capture millions of cell experiments per week, feeding results back into the platform in a continuously improving feedback loop. This approach has demonstrated significant improvements in speed, efficiency, and reduced costs from hit identification to IND-enabling studies compared to traditional pharmaceutical company averages. The company has developed an advanced pipeline of potential first-in-class and best-in-class treatments targeting conditions with high unmet need, including aggressive cancers such as advanced solid tumors, B-cell malignancies, and lymphomas, as well as rare diseases like familial adenomatous polyposis and hypophosphatasia. Multiple programs are currently in clinical trials, including the TUPELO, ELUCIDATE, DAHLIA, EXCELERIZE, and ENLYGHT studies. Recursion partners with pharmaceutical industry leaders and technology giants like NVIDIA, with whom they built BioHive-2, biopharma's most powerful supercomputer. The company is headquartered in Salt Lake City, Utah, and is a proud founding member of BioHive, the fastest-growing life sciences community in the nation.
Company description Exscientia official website
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01 · Operating footprint
Company-profile context for clinical focus, customers, deployment, integration, milestones, and partnerships.
On Premise · Other deployment with recorded integration context.
Company milestones
First patient dosed in Phase 1 clinical study of REC-3565 for B-cell lymphomas. Positive Phase 1b/2 results from ongoing REC-4881 TUPELO trial. Built BioHive-2 supercomputer with NVIDIA.
Partnerships
02 · Flagship portfolio
Selected source-backed Company products and the available commercial context.
Biopharma's most powerful supercomputer for AI drug discovery
Selective MALT1 inhibitor for B-cell lymphomas
Treatment for familial adenomatous polyposis
AI-driven drug discovery and development platform
03 · Research intelligence
Publications, preprints, clinical validation, and regulatory records in Evidence Position order.
Publications, clinical validation, and regulatory records connected to this Company appear here.
Research
Journal of medicinal chemistry · Feb 26, 2026
Computational design of therapeutic antibodies with improved developability: efficient traversal of binder landscapes and rescue of escape mutations.mAbs · Dec 1, 2025
Structural Biology Enabling Drug Discovery.Journal of medicinal chemistry · Nov 27, 2025
New Machine Learning Models for Predicting the Organic Cation Transporters OCT1, OCT2, and OCT3 Uptake.ACS omega · Sep 30, 2025
Optimizing Absolute Binding Free Energy Calculations for Production Usage.Journal of chemical theory and computation · Sep 9, 2025
Basic Stability Tests of Machine Learning Potentials for Molecular Simulations in Computational Drug Discovery.Journal of chemical information and modeling · Sep 8, 2025
Clinical validation
NCT05985655 · Sponsor · RECRUITING
Dose Determining Study of EXS73565 in Participants With Relapsed or Refractory B-Cell MalignanciesNCT06980116 · Sponsor · RECRUITING
Dose Determining Study of EXS74539 (REC-4539) in Participants With Select Solid TumorsNCT07517198 · Sponsor · RECRUITING
Association of Ex Vivo Drug Response ( EVDR) and Clinical Outcome in Acute Myeloid Leukaemia (EXCYTE-2)NCT06648512 · Sponsor · COMPLETED
Association of Ex Vivo Drug Response (EVDR) and Clinical Outcome in Ovarian CancerNCT06068738 · Sponsor · TERMINATED
Study to Assess EXS21546 in Combination in Patients With Advanced Solid TumoursNCT05920408 · Sponsor · TERMINATED
Regulatory
No linked records are currently available.
04 · Company-reported outcomes
Company-reported outcomes and customer stories are distinct from linked Research Intelligence evidence.
From hit identification to IND-enabling studies compared to traditional pharmaceutical company averages
Demonstrated reduced costs from hit identification to IND-enabling studies
Mission to reduce the massive 90% failure rate of traditional drug discovery
Demonstrated significant improvements in drug discovery speed and efficiency from hit identification to IND-enabling studies
Significant improvements in speed, efficiency, and reduced costs compared to traditional pharmaceutical company averages
Built BioHive-2, biopharma's most powerful supercomputer to process massive biological and chemical datasets for AI drug discovery
Enabled processing of >50 petabytes of proprietary biological and chemical data
05 · Leadership
Leadership profiles and professional links from the current Company record.
No active leadership profiles are currently listed.
06 · Company updates
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No Company updates are currently listed.
07 · HAIC coverage
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08 · Official presence
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09 · Market pathway
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Market context
Companies using AI, machine learning, or computational biology to discover new drug candidates, identify drug targets, predict drug efficacy, or accelerate pharmaceutical development. Includes both small molecule and biologics development, precision oncology drug discovery, and AI-driven target identification and molecule design.
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